Objective:To investigate the therapeutic effects of Xianglian capsule on acute ulcerative colitis

anti-inflammatory

analgesic and anti-diarrheal functions. Method: Sixty SD rats were randomly divided into normal control group

model group

Xieli-xiao group

low

medium

high doses of Xianglian group (0.122

0.243

0.486 g·kg-1). Using acetic acid method to establish the rat models of ulcerative colitis. Gross morphological changes of rat colon and colonic mucosal damage index (CMDI) score

and rat colon weight

pathology was observed after after continuous administration for 10 days. Anti-inflammatory

analgesic and anti-diarrheal efficacys were observed with ear swelling models induced by xylene

diarrheal models induced by senna and acetic acid writhing test. Result: Compared with the model group

the Xianglian capsule medium dose group (0.243 g·kg-1) can obviously reduce on rat intestinal mucosal damage induced by acetic acid

reduce inflammation

necrosis

edema and inflammatory cell invasion; Xianglian capsule medium dose group (0.243 g·kg-1) inhibited the degree of ear swelling (P<0.01)

decrease frequency of diarrhea (P<0.05)

shortened small intestine advance distance (P<0.05)

reduce the writhing times of (P<0.01). Conclusion: Xianglian capsule can significantly inhibit the ulcer and have anti-inflammatory

analgesic action and inhibition of intestinal peristalsis.