Preparation and Release Investigation of Triptolide-Folic Acid Chitosan Nanoparticle
|更新时间:2024-01-04
|
Preparation and Release Investigation of Triptolide-Folic Acid Chitosan Nanoparticle
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 22, Pages: 49-52(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
TONG Wen-ting, LIU Bo, ZHANG Rui, et al. Preparation and Release Investigation of Triptolide-Folic Acid Chitosan Nanoparticle[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 49-52.
DOI:
TONG Wen-ting, LIU Bo, ZHANG Rui, et al. Preparation and Release Investigation of Triptolide-Folic Acid Chitosan Nanoparticle[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 49-52.DOI:
Preparation and Release Investigation of Triptolide-Folic Acid Chitosan Nanoparticle
Objective:To prepare triptolide- folic acid chitosan nanoparticle with targeting
and study on its in vitro release property. Method: With particle size and PDI as indexes
influence of solution pH
reaction temperature
proportion and mass concentration of chitosan and sodium polyphosphate on preparation technology of chitosan nanoparticle were investigated by single factor test and orthogonal design;Optimum preparation technology was selected by coupling ratio of triptolide and chitosan
amino reaction of triptolide
folic acid active ester and chitosan
triptolide-folic acid chitosan nanoparticle was prepared by ionic crosslinking method.In vitro release property was examined by HPLC. Result: Optimum preparation technology was as following:reaction temperature 25 ℃
solution pH of 3.5
chitosan-sodium polyphosphate 3∶1
the mass concentration of chitosan and sodium polyphosphate of all 0.3%.Average particle size of prepared nanoparticle was about 170 nm
PDI was about 0.21.Release rate of drug-loading nanoparticle reached equilibrium after 4 h
the maximum release rate was about 68%. Conclusion: Quality of triptolide-folic acid chitosan nanoparticle was stable and reliable
which was prepared by optimized preparation technology
Study on Preparation of Chrysophanol Microcapsule and its in vitro Release Behavior
Preparation and Release of Sinomenine Hydrochloride-loaded Chitosan Nanoparticles
Preparation Technology of Total Saponins from Combined with Icariin Chitosan Microspheres
Preparation and Release Behavior Investigation of Ursolic Acid Liposome
Preparation and in vitro Release of Sinomenine Hydrochloride-loaded Chitosan Nanoparticles
Related Author
YAN Chun-lin
ZHANG Ji
ZHANG Dan-shen
ZHANG Li
XUE Gui-ping
WANG Shu
LIN Xiao-jie
ZHANG Hua
Related Institution
Tianjin Municipal Key Lab of Modification and Functional Fibers,Tianjin Polytechnic University
School of Sciences of Tianjin Polytechnic University
College of Traditional Chinese Medicine,Yunnan Provincial Key Laboratory of Research on External Drug Delivery System and Preparation Technology in Universities,Yunnan Key Laboratory of Sustainable Utilization of Southern Medicine,Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine
Laboratory Animal Science and Technology Center,Jiangxi University of Chinese Medicine
National Key Laboratory of Modern Chinese Medicine Creation of Classic Prescriptions