Objective: To observe the effect of Acupoint injection combined with Chinese herbal medicine on cervical vertebra disease of vertebral artery type. Method: Eighty cases of cervical vertebra disease of vertebral artery type were divided into two groups of 40 cases randomly. The treatment group was treated with acupoint injection (Compound Danshen injection) combined with oral Chinese herbal medicine (Banxia Baizhu Tianma decoction)

and the control group was treated with Chinese drugs orally (Banxia Baizhu Tianma decoction)

then the efficacy of two groups was compared. The blood flow velocity in vertebral artery (VA)

basilar artery (BA) of 2 groups after treatment was measured by transcranial Doppler (TCD). The levels of nitric oxide (NO) and endothelin (ET) in plasma were also determined. Result: Total effective rate of the treatment group was 95.00%

and total effective rate of the control group was 77.50%. There was significant difference between two groups (P<0.01). The blood flow velocity in VA

BA of 2 groups after treatment was significantly faster than those before treatment (P<0.05). The VA blood flow velocity of treatment group

compared with the control group

was significant high (P<0.05). The NO level in the treatment group was high than that in the controls

and the level of ET in the treatment group was low than that in the controls (P<0.05

P<0.01). Conclusion: Acupoint injection combined with Chinese herbal medicine is especially effective for treatment of cervical vertebra disease of vertebral artery type.