Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia
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Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 3, Pages: 97-100(2013)
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Published:2013
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LI Yao-hua, CAI Le, ZHONG Ming, et al. Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 97-100.
DOI:
LI Yao-hua, CAI Le, ZHONG Ming, et al. Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 97-100.DOI:
Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia
Objective:To create a determination method and to explore the preliminary stability of formulated granules of detoxification and anti-leukaemia. Method: HPLC was performed on a C18 column (4.6 mm×250 mm
5 μm) using methanol-0.1%H3PO4 (34∶66) as the mobile phase at the detection wavelength of 335 nm to determine scutellarin of barbata. The preliminary stability of three batches samples was also investigated. Result: The linear range of scutellarin was 0.260-2.60μg. The mean recovery was 100.7% with RSD 2.6% (n=6). The preliminary stability tests showed that formulated granules met the specification in the appearance
size
moisture content
load difference
solubility and determination of compliance. Conclusion: The method of determination is feasible
formulated granules could be controlled in quality with good stability.