Analysis of 14 Active Compositions Alignment in Gengen Qinlian Decoction by HPLC

MAO Ying; ZHANG Gui-jun; LIU Jing-jing; DONG Wen-xi; ZHANG Ya-nan

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Analysis of 14 Active Compositions Alignment in Gengen Qinlian Decoction by HPLC

更新时间：2024-01-04

- Analysis of 14 Active Compositions Alignment in Gengen Qinlian Decoction by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 108-113(2013)
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- Published：2013
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MAO Ying, ZHANG Gui-jun, LIU Jing-jing, et al. Analysis of 14 Active Compositions Alignment in Gengen Qinlian Decoction by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 108-113.
DOI：

MAO Ying, ZHANG Gui-jun, LIU Jing-jing, et al. Analysis of 14 Active Compositions Alignment in Gengen Qinlian Decoction by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 108-113. DOI：

摘要

目的: 分析测定葛根芩连汤中的14种药效组分

为建立其与临床疗效对应的质量标准提供技术和思路。方法: 按照传统经方制备葛根芩连汤

采用高效液相色谱法(HPLC)对其药效组分进行测定。结果: 葛根芩连汤中的14种药效组分

即葛根素、大豆苷、大豆苷元、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、盐酸小檗碱、盐酸巴马汀、盐酸药根碱、盐酸表小檗碱、盐酸黄连碱、甘草酸铵、甘草苷的含量分别为1.673 7%

0.153 3%

0.047 3%

0.448 0%

0.091 6%

0.012 3%

0.006 7%

0.095 5%

0.034 3%

0.043 8%

0.036 0%

0.048 3%

0.110 3%

0.158 0%。结论: 所采用的HPLC法快速、简便

所测得的葛根芩连汤中的药效组分可作为其质量控制的科学指标。

Abstract

Objective: To determine 14 active compositions alignment (ACA) in Gengen Qinlian Decoction so as to provide technology and ideas for the establishment of quality standard in accordance with its therapeutic. Method: Gengen Qinlian Decoction was prepared by traditional method

the ACA were determined by high performance liquid chromatography (HPLC). Result: The 14 ACA in Gengen Qinlian Decoction were puerarin

daidzin

daidzein

baicalin

wogonoside

baicalein

wogonin

berberine hydrochloride

palmatine hydrochloride

jatrorrhizine hydrochloride

epiberberine hydrochloride

coptisine hydrochloride

ammonium glycyrrhizinate

liquiritin. The content of ACA (%) were 1.673 7%

0.153 3%

0.047 3%

0.448 0%

0.091 6%

0.012 3%

0.006 7%

0.095 5%

0.034 3%

0.043 8%

0.036 0%

0.048 3%

0.110 3%

0.158 0%. Conclusion: The HPLC method used is rapid and simple

and the ACA in Gengen Qinlian Decoction can be used as the scientific indicator of quality control.

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