Objective: To observe effects of different boiling methods of Maxing Shigan decoction on hypoxia-inducible factor 1α(HIF-1α)and MUC5AC in the airway of asthmatic model mice. Method: 50 qualified mice were randomly divided into 5 groups with 10 in each(normal control group

model group

Maxing Shigan decoction divided boiling group

Maxing Shigan decoction same boiling group A and Maxing Shigan decoction same boiling group B)

except for the normal control group

mice in all other groups were sensitized with ovalbumin(OVA)by intraperitoneal injection

and asthmatic models were made by atomization inhalation stimulation with low concentration of OVA.Treatment groups were administered medicine for 7 days from stimulating

MUC5AC in bronchial lavage fluid and HIF-1α in lung tissues of all groups were determined. Result: Maxing Shigan decoction divided boiling group reduceed the concentration of MUC5AC and HIF-1α was better than group A and group B(P<0.01). Conclusion: Maxing Shigan decoction boiling method with Herba Ephedrae scum eliminated had the best effects

its effect was optimum in reducing mucus hypersecretion in the airway of bronchial asthma and improving acute hypoxia environment.