Effects of Yiqi Yangxue Wenyang Formula on Interstitial Cells of Cajal in the Rat colon of Constipation caused by Laxatives
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Effects of Yiqi Yangxue Wenyang Formula on Interstitial Cells of Cajal in the Rat colon of Constipation caused by Laxatives
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 2, Pages: 219-222(2013)
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Published:2013
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WU Zhi-jiu, WANG Fei. Effects of Yiqi Yangxue Wenyang Formula on Interstitial Cells of Cajal in the Rat colon of Constipation caused by Laxatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 219-222.
DOI:
WU Zhi-jiu, WANG Fei. Effects of Yiqi Yangxue Wenyang Formula on Interstitial Cells of Cajal in the Rat colon of Constipation caused by Laxatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 219-222.DOI:
Effects of Yiqi Yangxue Wenyang Formula on Interstitial Cells of Cajal in the Rat colon of Constipation caused by Laxatives
Objective: To study the effects and mechanism of Yiqi Yangxue Wenyang formula on interstitial cells of cajal in the rat colon of constipation caused by laxatives. Method: The rat constipation model was caused by laxatives on. First day rats were ig given rhubarb 200 mg· kg-1· d-1
second day given 400 mg·kg-1· d-1 for 3 months
until half rats appeared diarrhea. The modelling rats were treated with Yiqi Yangxue Wenyang formula for two weeks
interstitial cells of cajal in colon was observed by RT-PCR. Result: The interstitial cells of cajal in rat colon in the Yiqi Yangxue Wenyang formula high dose group was 0.365 08±0.047
the medium group was 0.370 97±0.040
that was higher than that in the model group is 0.298 55±0.046(P<0.05). Conclusion: The Yiqi Yangxue Wenyang formula can treat constipation by adjust interstitial cells of cajal in colon.
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