Effect of Ziying Qingre Prescription on Proliferation of Sebaceous Gland in Golden Hamster
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Effect of Ziying Qingre Prescription on Proliferation of Sebaceous Gland in Golden Hamster
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 4, Pages: 206-208(2013)
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Published:2013
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XU Ping, ZHAO Xiao-ling, CHEN Li, et al. Effect of Ziying Qingre Prescription on Proliferation of Sebaceous Gland in Golden Hamster[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 206-208.
DOI:
XU Ping, ZHAO Xiao-ling, CHEN Li, et al. Effect of Ziying Qingre Prescription on Proliferation of Sebaceous Gland in Golden Hamster[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 206-208.DOI:
Effect of Ziying Qingre Prescription on Proliferation of Sebaceous Gland in Golden Hamster
we aim to investigate mechanism of Ziying Qingre prescription on acne. Method: The animals were randomly divided into 4 groups
namely blank control group
positive control group
high and low dosage of Ziying Qingre prescription. They were respectively fed with saline solution
antisterone(10 mg·kg-1)
Ziying Qingre prescription(18
9 g·kg-1) for 4 weeks. We measured the greatest transverse and greatest longitudinal diameter of bilateral sebaceous gland plaques with vernier caliper under strong light. The size change (greatest transverse diameter multiply greatest longitudinal diameter)and histopathology of sebaceous gland plaques were observed. Result: The size of sebaceous gland plaques of high dosage group were decreased (P<0.05) compared to the blank control groupHistopathology showed Ziying Qingre prescription made the numbers of sebaceous gland layers decreased
gland atrophy
arrangmentloose. Conclusion: Ziying Qingre prescription can suppress the proliferation of sebaceous glandwhich may be one of the mechanisms in treatment of acne.