Determination of Salvianolic Acid B in Danxi Granula by HPLC

LI Xiang; LIU Gui-yang; MA Jian-li; ZHOU Liang; WANG Fang

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Determination of Salvianolic Acid B in Danxi Granula by HPLC

更新时间：2024-01-04

- Determination of Salvianolic Acid B in Danxi Granula by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 135-136(2012)
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- Published：2012
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LI Xiang, LIU Gui-yang, MA Jian-li, et al. Determination of Salvianolic Acid B in Danxi Granula by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 135-136.
DOI：

LI Xiang, LIU Gui-yang, MA Jian-li, et al. Determination of Salvianolic Acid B in Danxi Granula by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 135-136. DOI：

摘要

目的: 建立测定丹膝颗粒中丹酚酸B的含量。方法: 采用高效液相色谱法

Agilent Eclipse XDB-C18色谱柱(4.6 mm×150 mm

5 μm)

甲醇-1%甲酸溶液(40∶60)

检测波长286 nm

流速1.0 mL·min-1

柱温30 ℃。结果: 丹酚酸B在0.207~8.264 μg与其峰面积线性关系良好(r=0.999 9)

平均回收率分别为100.20%

RSD 1.14%。结论: 方法专属性强、重复性好、结果准确可靠

可用于丹膝颗粒的质量控制和评价方法。

Abstract

Objective:To establish an HPLC method for determination of salvianolic acid B in Danxi Granula. Method: The Agilent Eclipse XDB-C18 (4.6 mm×150 mm

5 μm) was used; the flow rate was 1.0 mL·min-1; the mobile phase consisted of methanol-1% formic acid (40∶60) with the detection wavelength at 286 nm; the column temperature was at 30 ℃. Result: A good linear correlation of salvianolic acid B was observed within the range of (0.207-8.264) g (r=0.999 9)

with the average recovery was 100.20% (RSD 1.14%). Conclusion: The method is simple and accurate with good specificity and reproducibility

and it can be used for the quality control and evaluation of Danxi Granula.

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Related Institution

Chengde Jingfukang Pharmaceutical Group Co.Ltd,New Excipients of Traditional Chinese MedicineEngineering Research Center of Hebei Province

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Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences and Peking Union Medical College

Jiangxi University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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