Optimization of Shaping Prescription of Lutein Microencapsulation Dispersible Tablet

GENG Meng-yuan; LU Ping; YANG Li-li; SUN Jiang; WANG Xin-chun

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Optimization of Shaping Prescription of Lutein Microencapsulation Dispersible Tablet

更新时间：2024-01-04

- Optimization of Shaping Prescription of Lutein Microencapsulation Dispersible Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 45-48(2012)
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- Published：2012
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GENG Meng-yuan, LU Ping, YANG Li-li, et al. Optimization of Shaping Prescription of Lutein Microencapsulation Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 45-48.
DOI：

GENG Meng-yuan, LU Ping, YANG Li-li, et al. Optimization of Shaping Prescription of Lutein Microencapsulation Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 45-48. DOI：

摘要

目的: 优选叶黄素微囊分散片的成型处方。方法: 以外观、混悬性、崩解时间及溶出度为综合评价指标

采用单因素试验确定填充剂及润滑剂种类和用量、崩解剂、润湿剂及溶胀性辅料的种类

通过正交试验优选叶黄素微囊分散片的成型工艺处方。结果: 最佳处方为以25%羧甲基淀粉钠(CMS-Na)-交联聚乙烯吡咯烷酮(PVPP)(1∶1.5)为崩解剂

6%羟丙基纤维素(HPC)为溶胀性辅料

70%乙醇溶液为润湿剂

所制备的分散片在80 s内完全崩解

10 min溶出度>90%。结论: 优选的处方辅料种类及比例适宜、片面光洁

崩解迅速、溶出度高

具有良好的开发前景。

Abstract

Objective:To optimize forming prescription of lutein microcapsule dispersible tablet. Method: With appearance

suspension

disintegration time and dissolution as comprehensive evaluation indexes

type and amount of filler and lubricant

type of disintegrating agent

wetting agent and swelling accessories were determined by single factor test

forming technology prescription of lutein microcapsule dispersible tablet was optimized by orthogonal test. Result: Optimum forming prescription was:with consisted of 25%CMS-Na and PVPP(1∶1) as disintegrating agent

6% HPC as swelling accessory

and 70% ethanol as wetting agent.These prepared dispersible tablet could disintegrate completely within 80 s

dissolution was more than 90% within ten min. Conclusion: This optimized formulation was rational and stable with smooth appearance

rapid disintegration

high dissolution and good development prospect.

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Related Institution

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Beijing Key Laboratory of Chinese Materia Pharmacology，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

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