Effect of Bushen Huoxue Decoction on Cardiac Function and Expression of AQP-2 in CHF Rats

SONG Ye-lin; LI Jie; YU Guang-yu; NIE Ying-ying; ZHU Dong-dong; LI Yu-zhen

您当前的位置：

首页 >

文章列表页 >

Effect of Bushen Huoxue Decoction on Cardiac Function and Expression of AQP-2 in CHF Rats

更新时间：2024-01-04

- Effect of Bushen Huoxue Decoction on Cardiac Function and Expression of AQP-2 in CHF Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 261-264(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
SONG Ye-lin, LI Jie, YU Guang-yu, et al. Effect of Bushen Huoxue Decoction on Cardiac Function and Expression of AQP-2 in CHF Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 261-264.
DOI：

SONG Ye-lin, LI Jie, YU Guang-yu, et al. Effect of Bushen Huoxue Decoction on Cardiac Function and Expression of AQP-2 in CHF Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 261-264. DOI：

摘要

目的: 探讨补肾活血汤对慢性心衰大鼠的疗效及心肾靶向功能的作用机制。方法: 采用32周龄以上自发性高血压大鼠(SHR)为慢性心衰大鼠

分为补肾活血汤高、中、低剂量组(5.7

2.85

1.43 g ·kg-1)

卡托普利组0.05 g ·kg-1、模型对照组

Wistar大鼠为正常对照组

予以相应药物干预

8周后检测超声心动指标及肾脏组织水通道蛋白2(AQP-2)的水平。结果: 补肾活血汤可延缓心衰大鼠的左室重构进程

左室后壁厚度(LVAWT)由2.93 mm降至2.72 mm、左室舒张末期内径(LVEDD)由7.65 mm降至7.57 mm、左室收缩末期内径(LVESD)由3.87 mm降至3.68 mm、短轴缩短率(LVFS)由0.44提高至0.48、左室射血分数(LVEF由0.42提高至0.47)

药物高、中、低剂量组较模型组有统计学意义(P<0.05);可降低心衰大鼠肾脏组织AQP-2的表达

平均由2.1%降至1.63%(P<0.05)

其作用均与药物浓度呈正相关。结论: 补肾活血汤可改善慢性心衰大鼠的心功能

并通过降低肾脏组织AQP-2的水平

从而发挥利水改善心室重构的作用。

Abstract

Objective: To discusse effect of Bushen Huoxue decoction (BSHXD) on chronic heart failure in rat as well as mechanism. Method: The spontaneously hypertensive rats (SHR) were radomly divided into Bushen Huoxue decocotion high

medium and low dose group

Captopril group

the model group

normal rats were as normal group.Corresponding drugs were given for 8 weeks

then echocardiography index and kidney tissue aquaporin 2(AQP-2) level were measured. Result: BSHXD could delay left ventricular remodeling process

high

medium and low dose compared with model group showed statistically significant (P<0.05); and reduce tissue AQP-2 expression (P<0.05)

which was positively correlated with drug concentration. Conclusions: Bushen Huoxue decoction can improve cardiac function and reduce tissue AQP-2 level.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective Effect of Shengxiantang on Myocardial Microvascular Injury in Rats with Chronic Heart Failure

Effect of Yiqi Wenyang Huoxue Lishui Components on Cardiac Function and Mitochondrial Energy Metabolism in CHF Rats

Effect of Qili Qiangxin Capsule on Cardiac Function and Plasma Antidiuretic Hormone in Patients with Chronic Heart Failure

Related Author

GAO Hui

YANG Zeqi

GAO Fan

LI Hongjing

LU Aiyangzi

LIU Xingchao

GUO Qiuhong

GAO Hui

Related Institution

Hebei University of Chinese Medicine

Hebei Provincial Hospital of Traditional Chinese Medicine（TCM）

Hebei Technology Innovation Center for TCM Formula Preparations

Hebei Higher Education Institute Applied Technology Research Center for TCM Development and Industrialization

Hebei Higher Education Institute Applied Technology Research Center on TCM Development and Industrialization

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰