Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanol Extracts of Dong-medicine

MO Jia-jia; XU Mu-die; YANG Dan-dan; HUANG Zhen

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Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanol Extracts of Dong-medicine

更新时间：2024-01-04

- Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanol Extracts of Dong-medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 258-260(2012)
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- Published：2012
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MO Jia-jia, XU Mu-die, YANG Dan-dan, et al. Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanol Extracts of Dong-medicine [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 258-260.
DOI：

MO Jia-jia, XU Mu-die, YANG Dan-dan, et al. Experimental Study on Anti-inflammatory and Analgesic Effects of Ethanol Extracts of Dong-medicine [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 258-260. DOI：

摘要

目的: 观察侗族药羊耳菊醇提物的抗炎镇痛作用。方法: 小鼠分为空白对照组

羊耳菊醇提物(生药)2.5

5 g ·kg-1剂量组和阳性对照阿司匹林0.25 g ·kg-1组。采用二甲苯致小鼠耳肿胀法、小鼠腹腔毛细血管通透性亢进法观察其抗炎作用;采用小鼠醋酸扭体法、热板法观察其镇痛作用。结果: 羊耳菊醇提物(5 g ·kg-1)显著抑制二甲苯所致小鼠耳肿胀(P<0.05)及醋酸所致小鼠腹腔毛细血管通透性增高(P<0.01);羊耳菊醇提物(5 g ·kg-1)显著减少醋酸致小鼠20 min内扭体次数

提高热板致痛小鼠痛阈值(P<0.01

P<0.01)。结论: 羊耳菊醇提物具有较好的抗炎镇痛作用。

Abstract

Objective: To observe anti-inflammatory and analgesic effects of ethanol extracts of Dong-medicine Inual cappa. Method: Mice divided into blank control group

low dose group and high dose group (2.5

5 g·kg-1) of ethanol extracts of I. cappa DC. and positive control group of aspirin (0.25 g·kg-1). The anti-inflammatory action was assessed by tests including HAc-induced peritoneal capillary permeability in mice

xylene-induced ear edema in mice.The analgesic effect was verified by HAc-induced writhing response in mice and hot-plate test. Result: The dose group of the ethanol extracts of I. cappa DC. (5 g·kg-1)could significantly inhibit the ear edema induced by xylene (P<0.05)and very significantly inhibit the phlogistic infiltration induced by acetic acid in mice(P<0.01).The dose group of the ethanol extracts of Inual cappa DC. (5 g·kg-1)could significantly reduced writhes of abdominal cavity induced by acetic acid in 20 minutes and increased the pain threshold in the hot-plate test(P<0.01

P<0.01). Conclusion: Ethanol extracts of Inual cappa DC. have obvious anti-inflammatory and analgesic effects.

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