Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis

LI Fu-juan

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Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis

更新时间：2024-01-04

- Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 4, Pages: 297-299(2013)
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- Published：2013
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LI Fu-juan. Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 297-299.
DOI：

LI Fu-juan. Clinical Study on Dahuang Zhechong Capsule for Treating Endometriosis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 297-299. DOI：

摘要

目的: 探讨大黄蛰虫胶囊治疗子宫内膜异位症的疗效及对前列腺素(PG)的影响。方法: 67例患者随机分为对照组34例和观察组33例。对照组口服米非司酮

12.5 mg/次

1次/d;观察组口服大黄蛰虫胶囊

5粒/次

2次/d。疗程均为12周。观察VAS评分

改良的B&B多维量表及测定血浆中前列腺素PGs。结果: 治疗后观察组VAS评分低于对照组(P<0.05);观察组B&B多维量表评分低于对照组(P<0.01);治疗后观察组F2a(PGF2a)

前列腺素E2(PGE2)及血栓素B2(TXB2)水平低于对照组

6酮前列腺素F1a(6-keto-PGF1a)高于对照组(P<0.05

P<0.01)。结论: 大黄蛰虫胶囊能改善子宫内膜异位症患者临床症状、体征;可能是通过调节PG水平发挥其缓解痛经等症状。

Abstract

Objective: To explore the effect of Dahuang Zhechong capsule (DZC) for treating endometriosis and the influence to prostaglandin (PG). Method: Sixty-seven cases of patients with endometriosis were randomly divided into control group and experimental group

while control group was received mifepristone (12.5 mg daily)

and experimental group received DZ

5 tablets bid. The treatment was lasted for 12 weeks. Score of visual analogue scale(VAS) and the score of B&B multidimensional scale were investigated

and the level of plasma PGs were determined. Result: VAS score in the experimental group was lower than that in the control group (P<0.05). B&B multidimensional scale score in the experimental group was lower than that in the control group (P<0.01). Level of prostaglandin F2a (PGF2a)

prostaglandin E2(PGE2) and thromboxane B2 (TXB2) of experimental group was lower than those of control group (P<0.05). But level of 6-keto-PGF1a of experimental group was higher than that of control group (P<0.01). Conclusion: For treating patients with endometriosis

DZC can improve symptom and signs. The effect of alleviating dysmenorrhea is likely related to regulation of levels of PGs.

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Related Institution

Beijing Hospital of Traditional Chinese Medicine，Capital Medical University，Beijing Institute of Traditional Chinese Medicine， Beijing Evidence-based Chinese Medicine Center

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Center for Evidence-based Chinese Medicine， Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

College of Pharmacy，Gansu University of Chinese Medicine

Affiliated Hospital of Gansu University of Chinese Medicine

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