Content Determination of Methyl Nonyl Ketone in Maozhiqing Oral Liquid by Gas Chromatography

WU Ri-tu; XU Xiao-li; LIU Shi-jie; WEI Wen-jing; LIU Tong-xiang

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Content Determination of Methyl Nonyl Ketone in Maozhiqing Oral Liquid by Gas Chromatography

更新时间：2024-01-04

- Content Determination of Methyl Nonyl Ketone in Maozhiqing Oral Liquid by Gas Chromatography
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 64-66(2012)
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- Published：2012
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WU Ri-tu, XU Xiao-li, LIU Shi-jie, et al. Content Determination of Methyl Nonyl Ketone in Maozhiqing Oral Liquid by Gas Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 64-66.
DOI：

WU Ri-tu, XU Xiao-li, LIU Shi-jie, et al. Content Determination of Methyl Nonyl Ketone in Maozhiqing Oral Liquid by Gas Chromatography[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 64-66. DOI：

摘要

目的: 建立毛支清口服液中甲基正壬酮的含量测定方法。方法: 采用气相色谱法。Rtx-1毛细管色谱柱(0.25 mm×30 m

0.25 μm)

FID检测器

柱温80℃(2 min)

以10℃ ·min-1升至220℃

再以20℃ ·min-1升至270℃;进样口温度240℃

检测器温度280℃

进样量1 μL

分流比30:1

载气为氮气

柱流量1.13 mL ·min-1

空气流量400 mL ·min-1;氢气流量40 mL ·min-1。结果: 甲基正壬酮进样浓度为0.032 1~0.641 6 g ·L-1时与峰面积呈良好的线性关系

回归方程为Y=3.00×106X-19 844(r=0.999 8)

平均回收率97.76%

RSD 1.82%。结论: 所建立的气相色谱方法简便、准确、灵敏度高、重复性好

可作为毛支清口服液的质量控制标准。

Abstract

Objective: To establish an method for determination of methyl nonyl ketone in Maozhiqing Oral Liquid. Method: The methyl nonyl ketone was determined by gas chromatography with Rtx-1 capillary chromatographic column(0.25 mm×30 m

0.25 μm). Column temperature: 80℃ for 2 min

increased at 10℃·min-1 to 220℃

then 20℃·min-1 to 270℃. Injector temperature: 240℃

FID temperature: 280℃. Injector volume was 1 μL; Split ratio was 30: 1. Nitrogen was used as carrier gas

the flow of column was 1.13 mL·min-1. Air: 400 mL·min-1. Hydrogen: 40 mL·min-1. Result: Methyl nonyl ketone has a good linear relationship with the peak area within the range of 0.032 1-0.641 6 g·L-1 with an regression equation being Y=3.00×106X-19 844(r=0.999 8). The average recovery was 97.76% and the relative standard deviation was 1.82%. Conclusion: The established method of gas chromatography can be used for quality control of Maozhiqing Oral Liquid because of its simplicity

accuracy

high sensitive and good reproducibility.

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Related Institution

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Third Affiliated Hospital of Henan University of Chinese Medicine

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