Analysis of HPLC Fingerprints of Qingrejiedu Oral Liquid and Content of Four Main Factors

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Analysis of HPLC Fingerprints of Qingrejiedu Oral Liquid and Content of Four Main Factors

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- Analysis of HPLC Fingerprints of Qingrejiedu Oral Liquid and Content of Four Main Factors
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 98-101(2013)
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- Published：2013
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Analysis of HPLC Fingerprints of Qingrejiedu Oral Liquid and Content of Four Main Factors[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 98-101.
DOI：

Analysis of HPLC Fingerprints of Qingrejiedu Oral Liquid and Content of Four Main Factors[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 98-101. DOI：

摘要

目的: 研究清热解毒口服液的HPLC指纹图谱及测定其4种主要有效成分的含量

以建立其有效地质量评价方法。方法: 通过建立HPLC指纹图谱和含量测定方法

对市售的产品质量进行分析;色谱条件为Shim-Pack VP-ODS C18色谱柱(4.6 mm×250 mm

5 μm)

流动相甲醇-0.1%磷酸梯度洗脱

检测波长227 nm。结果: 得到色谱参数较好的HPLC指纹图谱

对10批次的市售清热解毒口服液指纹图谱进行了相似度评价

结果显示不同厂家的该制剂成分含量差异较大。结论: 该方法简便准确

灵敏度高、重复性好

可以作为清热解毒口服液的质量控制方法;市售的该品种的制剂有明显差异性。

Abstract

Objective: To determine Qingrejiedu oral liquid by HPLC fingerprint of the 4 major effective component content in order to establish effective quality evaluation method. Method: The determination of HPLC fingerprint was established to analyze the quality of products sold in the market. The chromatographic conditions were as follows: Shim-Pack VP-ODS C18 HPLC column (4.6 mm×250 mm

5 μm); mobile phase methanol-0.1% phosphate gradient elution

detection wavelength of 227 nm. Result: The chromatographic parameters of HPLC fingerprints were better. 10 batches of fingerprint evaluation by similarity showed that there were larger differences between sold in Qingrejiedu oral liquids by different manufacturers. Conclusion: The method is simple

accurate with high sensitivity and repeatability

which can serve as a quality control method of Qingrejiedu oral liquid; there are significant differences between the varieties of preparation sold in.

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Related Author

HOU Mengyu

ZHAO Xia

GUO Zhiyu

LIU Ting

MA Yuexing

YE Yaohui

SHAO Juan

XU Mengdan

Related Institution

Jiangxi University of Chinese Medicine

Nanchang Medical College

School of Pharmaceutical Sciences， Changchun University of Chinese Medicine

Jilin Ginseng Academy，Changchun University of Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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