Optimization of Matrix Formulation for Jiangni Cataplasma

ZHANG Hua-zhi; LIANG Guo-hua; YU Xiao

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Optimization of Matrix Formulation for Jiangni Cataplasma

更新时间：2024-01-04

- Optimization of Matrix Formulation for Jiangni Cataplasma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 38-41(2012)
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- Published：2012
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ZHANG Hua-zhi, LIANG Guo-hua, YU Xiao. Optimization of Matrix Formulation for Jiangni Cataplasma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 38-41.
DOI：

ZHANG Hua-zhi, LIANG Guo-hua, YU Xiao. Optimization of Matrix Formulation for Jiangni Cataplasma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 38-41. DOI：

摘要

目的: 优选降逆巴布贴的基质处方。方法: 以黏力、外观均匀性、涂展性及追随性为综合评价指标

选取黏着剂比例与用量、保湿剂用量、交联剂用量为考察因素

采用L16(45)正交试验优选辅料处方及工艺参数;以体外透皮释药率为指标

采用单因素试验优选透皮吸收剂的种类与用量。结果: 最佳基质处方为黏着剂(聚丙烯酸钠-CMC-Na 4∶3)-干膏粉(35∶100)

保湿剂(甘油)-干膏粉(160∶100)

交联剂(三氯化铝)-干膏粉(2∶100)

促渗剂(氮酮与丙二醇等质量比混合物)-干膏粉30∶100。结论: 该优选工艺稳定可行

为降逆巴布贴制备工艺参数的确定提供实验依据。

Abstract

Objective:To optimize matrix prescription of Jiangni cataplasma. Method: With adhesion

uniformity of appearance

spread property and follow as comprehensive evaluation indexes

proportion and dosage of adhesive

the amount of moisturizing agent and crosslinking agent were chosen as factors

adjuvant prescription and preparation technology parameters was optimized by L16(45) orthogonal test;With in vitro transdermal drug release ratio as index

type and amount of transdermal absorbent was optimized by single factor. Result: Optimal matrix formulation was:proportion of adhesives(sodium polyacrykate-CMC-Na 4∶3)

moisturizing agent(glycerol)

crosslinking agent(aluminum trichloride)

penetrating agent(azone-propylene 1∶1) to dry extract powder were 35∶100

160∶100

2∶100 and 30∶100

respectively. Conclusion: This optimized technology was stable and feasible

and it could provide experimental basis to define preparation technology parameter of Jiangni cataplasma.

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Related Institution

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