Objective: To explore the effect of Jiangtang Xiaozhi (JTXZ) tablets on decreasing levels of blood glucose and serum lipid in rats with type 2 diabetes and provide the experimental basis for the clinical therapy of type 2 diabetic mellitus(T2DM). Method: The rats were fed on a diet enriched in fat and glucose to induce insulin resistant. And a low dose streptozotocin (STZ) was injected intrapertoneally (25 mg·kg- 1) to induce hyperglycemia to establish T2DM. The experimental rats were divided into normal control group

model group

JTXZ tablets groups (8

4 and 2 g·kg-1)

metformin group (0.2 g·kg-1) and Jinqi Jiangtang tablets group(2 g·kg-1). After all the treatment groups were received their own medicine for 8 weeks

the rats were sacrificed and fasting blood glucose(FBG)

serum lipids (TC and TG)

insulin (INS) and tumor necrosis factor(TNF-α) were determined. A pathological examination was performed for the pancreas and the livers. Result: Hyperinsulinism with high level TC occured and the IR was successfully induced when the rats were fed on an enriched in fat and glucose diet for 4 weeks. Low dose of STZ were injected to establish T2DM. The FBG and TG in high dose of JTXZ tables group were significantly decreased (31.23%

P<0.01) and the INS were increased (P<0.05) comparing to the model rats. In the middle dose group the TG and TC were decreased significantly (P<0.01~P<0.05). The TNF-α in the 3 dose groups showed a decreasing trend. The morphological study demonstrated that number of islets markedly increased in high dose group compared to the model group (P<0.05). The liver steatosis in middle and low dose groups was significantly milder than that in model group (P<0.05). Conclusion: JTXZ tablets have obvious effects for decreasing levels of blood glucose and serum lipid in T2DM rats.