Objective:To investigate the clinical applications of Yunnan Baiyao powder (YBP) after cervical cold knife conization (CKC). Method:One hundred and twenty one cases of cervical intraepithelial neoplasia(CIN) grade III treated with CKC were randomly divided into postoperative suture group (control group

n=60) and non-suture YBP packing group (observation group

n=61). The control group was treated with CKC postoperative wound electrocautery

then followed by improved Sturmdorf law suture forming. The observation group was treated with wound electrocautery

and then given 4 g of YBP for spray and gauze. They were followed up for 2 years. The amount of postoperative bleeding

postoperative bleeding time

the average vaginal discharge fluid time and subsequent bleeding

cervical infections and cervical stenosis and other complications were observed. Result:The surgical duration

intraoperative and postoperative bleeding in the observation group were less than those in the control group (P<0.01). The mean bleeding time and the average time of vaginal discharge had no significant difference between the two groups; 5 patients (8.2%) had postoperative secondary bleeding in the observation group while the control group were 4 cases (6.6%)

and there were no significant differences; during the follow-up period

there were no cervical infection and cervical stenosis. Conclusion:CKC without suture wound and YBP after electrocautery for stopping bleeding can significantly reduce the operation time

reduce the intraoperative blood loss

it has low incidence of postoperative wound bleeding again. However

it does not increase postoperative infection and cervical canal stenosis and other complications. YBP is worth to be promoted for the application.