Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions

SUN Lei; MA Xiao-lan; WU Yang; Sun Tao; DAI Gui-dong

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Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions

更新时间：2024-01-04

- Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 6, Pages: 23-25(2013)
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- Published：2013
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SUN Lei, MA Xiao-lan, WU Yang, et al. Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 23-25.
DOI：

SUN Lei, MA Xiao-lan, WU Yang, et al. Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 23-25. DOI：

摘要

目的: 制备芦丁固体分散体

比较不同载体对芦丁固体分散体体外溶出度的影响。方法: 采用溶剂法制备固体分散体并考察其体外溶出度;考察不同载体对芦丁溶出度的影响

以差示热分析药物在载体中的存在状态。结果: 载体种类和用量对芦丁溶出影响显著

其中PVPK30作为载体时溶出效果最佳

芦丁以微晶无定形分散于载体中。结论: 溶剂法制得固体分散体中芦丁的溶出度和溶出速率均显著提高。

Abstract

Objective: To prepare rutin solid dispersions(RSD)

and compare influence of different carriers on in vitro dissolution of it. Method: RSD was prepared by solvent method and its in vitro dissolution was tested.Influence of different carriers on drug dissolution was evaluated.Differential scanning calorimetry (DSC) was used to examine presence state of rutin in carrier. Result: Types and amount of carriers had significant influence on rutin dissolution

PVPK30 was chosen as optimum carrier

DSC showed that rutin dispersed in PVPK30 with amorphous and microcrystalline. Conclusion: Rutin dissolution and dissolution rate of these prepared rutin-PVPK30 solid dispersions were significantly improved.

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SU Jian-chun

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Related Institution

Beijing Research Institute of Chinese Medicine， Beijing University of Chinese Medicine

College of Life Sciences， Beijing University of Chinese Medicine

College of Chinese Materia Medica， Beijing University of Chinese Medicine

College of Pharmacy, Shaanxi University of Chinese Medicine

Guizhou Provincial Engineering Center of Efficient Utilization of Natural Medicinal Resources, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Joint Key Laboratory of Guizhou Medical University-Guiyang City, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, School of Pharmaceutical Sciences, Guizhou Medical University

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