Optimization of Preparation Technology of Tanshinone Solid Dispersion Dripping Pills
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Optimization of Preparation Technology of Tanshinone Solid Dispersion Dripping Pills
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 3, Pages: 8-12(2013)
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Published:2013
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LI Na, CUI Han-ming, WU Ping, et al. Optimization of Preparation Technology of Tanshinone Solid Dispersion Dripping Pills[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 8-12.
DOI:
LI Na, CUI Han-ming, WU Ping, et al. Optimization of Preparation Technology of Tanshinone Solid Dispersion Dripping Pills[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 8-12.DOI:
Optimization of Preparation Technology of Tanshinone Solid Dispersion Dripping Pills
Objective:To optimize preparation technology of tanshinone solid dispersion dipping pills. Method: Independent variables were proportion of drugs and excipients
melting tempratrue
PEG4000-PEG6000
kind of solubilizer
with dissolution in 10 min of tanshinone was dependent variable
preparation technology of tanshinone solid dispersion was optimized by orthogonal design;Existential state of drugs in this solid dispersion was analyzed by DSC
X-ray and IR.At the same time
preparation technology parameters of tanshinone solid dispersion dripping pill was optimized. Result: Optimum preparation technology of solid dispersion was:proportion of drugs and pharmaceutic adjuvants 1∶5
melting tempratrue 70 ℃
PEG4000-PEG6000 1∶1
poloxamer as solubilizer;Though analysis of DSC
X-ray and IR
drugs were molecular state in tanshinone solid dispersion
prepared solid dispersion was filled-type solid solution;Optimum preparation technology of dripping pills was:1000cs dimethyl silicon oil as condensing agent
temperature 20 ℃
dropping distance 4 cm
dropping speed 30-40 d·min-1
the average cumulative dissolution of prepared dripping pill was 85%. Conclusion: Prepared tanshinone solid dispersion could significantly improve in vitro dissolution of tanshinone
this prepared tanshinone dripping pills could achieve requirements of immediate-release.
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Related Author
LI Na1
CUI Han-ming2
WU Ping2
LI Xiao-fang1
DONG Mei-hong
WANG Jin-yu
TONG Yan
LI Yan-ling
Related Institution
Guang’anmen Hospital, China Academy of Chinese Medical Sciences
Chengdu University of Traditional Chinese Medicine
Natural History Museum of China
Beijing Key Laboratory of Chinese Materia Pharmacology,Institute of Basic Medical Sciences, Xiyuan Hospital,China Academy of Chinese Medical Sciences