Gubenhuayufang on the Relapse of Ulcerative Colitis

FAN Dong-mei; RAO Jing; ZHANG Zheng-zheng; TAO Shuang-you; ZHUANG Kun-hai

您当前的位置：

首页 >

文章列表页 >

Gubenhuayufang on the Relapse of Ulcerative Colitis

更新时间：2024-09-23

- Gubenhuayufang on the Relapse of Ulcerative Colitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 272-275(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
FAN Dong-mei, RAO Jing, ZHANG Zheng-zheng, et al. Gubenhuayufang on the Relapse of Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 272-275.
DOI：

FAN Dong-mei, RAO Jing, ZHANG Zheng-zheng, et al. Gubenhuayufang on the Relapse of Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 272-275. DOI：

摘要

目的: 探讨固本化瘀方干预溃疡性结肠炎(UC)复发的疗效以及对血清肿瘤坏死因子(TNF-α)水平的影响。方法: 将84例UC患者随机分为治疗组44例和对照组40例

治疗组给予固本化瘀方加柳氮磺胺毗啶口服方案治疗;对照组仅给予柳氮磺胺毗啶口服

并以20例健康志愿者作为正常对照组。治疗3个月后观察两组近期临床总体疗效

随访6个月后观察两组复发情况

并检测两组治疗前后以及健康对照组血清TNF-α水平。结果: 治疗组近期临床总体疗效优于治疗组(P<0.05);治疗组复发率明显低于对照组(P<0.05);治疗组治疗后患者血清TNF-α水平明显高于对照组及健康对照组(P<0.05)

复发患者血清TNF-α水平高于未复发患者

组间存在极显著差异(P＜0.01)

治疗后、随访时

治疗组血清TNF-α水平皆显著低于对照组(P＜0.05);但随访时在两组间比较

无显著差异。结论: 健脾化瘀法治疗溃疡性结肠疗效显著

并可降低复发率

其抗复发作用机制可能是与抑制外周血炎性因子TNF-α的过度表达相关。

Abstract

Objective:To observe the therapeutic effect of Guben Huayufang for the relapse of ulcerative colitis(UC) and its influence on serum tumor necrosis factor-α(TNF-α). Method: Eighty-four patients with UC were divided into two groups randomly

44 cases in treatment group treated with the Guben Huayufang plus salazosulfapyridine and 40 cases in control group treated with salazosulfapyridine. And a normal control group with 20 healthy volunteers was set. After three months

the general therapeutic effect of the two groups and the relapse information were observed after 6 months

also the serum TNF-α were detect before and after the therapy in three groups. Result: The therapeutic effect of treatment group is better than control group(P<0.05); the relapse ratio of treatment group is lower than control group(P<0.05). After the treatment

the serum TNF-α in treatment group is higher than control group and healthy control group(P<0.05). And the serum TNF-α in the relapse patients is higher than patients who has not relapsed(P＜0.01). After the treatment

and during the follow-up

the serum TNF-α in treatment group is lower than control group(P＜0.05); but with no difference during the follow-up. Conclusion: The therapeutic effect of Guben Huayufang for UC is significant

and can lower the relapse ratio. The mechanism might be that it can lower the expression of serum TNF-α.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Gubenhuayufang on the Relapse of Ulcerative Colitis

Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis

Preventive and Therapeutic Effect of Banqiao Codonopsis Radix Polysaccharide Against Ulcerative Colitis in Rats

Effect of Fuzi Lizhong Tang on Expression of NF-B,TNF-,IL-1 of Spleen and Kidney Yang Deficiency Type Ulcerative Colitis Rats Through Enema

Huadu Yuyang Decoction Retention Enema in Treating 43 Cases with Ulcerative Colitis at Mild and Moderate Stage

Related Author

FAN Dong-mei1

RAO Jing2

ZHANG Zheng-zheng1

TAO Shuang-you3

ZHUANG Kun-hai1

WANG Yan-mei

KANG Mei-qing

CUI Yan-bing

Related Institution

Department of Gastroenterology,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

广州中医药大学

广州中医药大学脾胃研究所

Jiangxi University of Chinese Medicine

College of Food Science and Technology，Nanchang University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰