Objective: To investigate the liver protection of total flavones of Meconopsis quintuplinervia Regel(MQR) from Gansu Province in mice. Method: Fifty-five Kunming mice were randomly divided into five groups that were orally administered the total flavones of MQR (0.300

0.150

0.075 g· kg-1) or contrast solution once per day for 7 d. Except normal mice

all the other mice were injected intraperitoneally 0.15% carbon tetrachloride(CCl4)

1.5% paracetamol(AP) or 5% thioocetamide(TAA) once. All mice were executed after 16 h and collected serum and liver samples for determining alanine aminotransferase(ALT) and aspirate aminotransferase(AST) in serum and malondialdehyde (MDA)

superoxide dismutase (SOD) and glutathion peroxidase(GSH-Px) in liver. Result: The total flavones of MQR growing in Gansu Province can degrade the levels of ALT and AST in serum and MDA in hepatic tissue

upgrade the SOD and GSH-Px activity in hepatic tissue. Furthermore

their protective effects exhibit the dose-effect relationship. Conclusion: The total flavones of MQR from Gansu Province have some protective effects on acute hepatic injury induced by CCl4

AP or TAA in mice.