Interaction of Compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra on Thrombus Formation and Coagulation Time

LIU Li-na; LAN Yan-yu; ZHENG Lin; LI Yong-jun; HUANG Yong

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Interaction of Compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra on Thrombus Formation and Coagulation Time

更新时间：2024-01-04

- Interaction of Compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra on Thrombus Formation and Coagulation Time
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 157-160(2012)
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- Published：2012
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LIU Li-na, LAN Yan-yu, ZHENG Lin, et al. Interaction of Compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra on Thrombus Formation and Coagulation Time[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 157-160.
DOI：

LIU Li-na, LAN Yan-yu, ZHENG Lin, et al. Interaction of Compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra on Thrombus Formation and Coagulation Time[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 157-160. DOI：

摘要

目的: 研究灯盏细辛和赤芍配伍对血栓形成和凝血时间的作用。方法: 以大鼠动静脉旁路血栓形成和小鼠凝血时间为考察指标

采用正交实验设计和方差分析方法对灯盏细辛和赤芍配伍使用的药效数据进行统计学分析

判断两药是否存在交互作用。结果: 两药单味及配伍对大鼠动静脉旁路血栓形成的抑制作用以及对小鼠凝血时间的延长作用均具有统计学意义

配伍组对大鼠动静脉旁路血栓形成抑制存在交互作用(P<0.05)

对小鼠凝血时间延长亦存在交互作用(P<0.01)。结论: 灯盏细辛与赤芍两药合用对血栓形成和凝血时间具有明显的交互作用。

Abstract

Objective: To clarify the interaction of the compatibility Erigerontis Breviscapi and Radix Paeoniae Rubra on the thrombus formation and the coagulation time(CT). Method: The arteriovenous bypass thrombogenesis in rats and the CT in mice were as evaluation indicators to evaluate the interaction of the compatibility Erigerontis Breviscapi and Radix Paeoniae Rubra by orthogonal experimental design and variance analysis method

and then pharmacodynamic data were statistically analyzed and estimated whether the two kinds of medicines had interaction. Result: The different combinations of two kinds of medicines could remarkably inhibit the arteriovenous bypass thrombogenesis in rats and significantly prolong CT in mice. The compound compatibility had interaction. Conclusion: The compatibility of Erigeron Breviscapi and Radix Paeoniae Rubra has significant interaction on thrombosis and CT.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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The First Affiliated Hospital of Hunan University of Chinese Medicine

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Postdoctoral Mobile Station of Chinese Medicine, Shandong University of Traditional Chinese Medicine

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