Research on Urine Metabonomics of HIV/AIDS Patiens Based on HLPC-MS Technique

MA Su-na; XU Qian-lei; XIE Shi-ping; LIU Wei; CUI Yong-xia

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Research on Urine Metabonomics of HIV/AIDS Patiens Based on HLPC-MS Technique

更新时间：2024-01-04

- Research on Urine Metabonomics of HIV/AIDS Patiens Based on HLPC-MS Technique
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 153-156(2012)
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- Published：2012
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MA Su-na, XU Qian-lei, XIE Shi-ping, et al. Research on Urine Metabonomics of HIV/AIDS Patiens Based on HLPC-MS Technique[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 153-156.
DOI：

MA Su-na, XU Qian-lei, XIE Shi-ping, et al. Research on Urine Metabonomics of HIV/AIDS Patiens Based on HLPC-MS Technique[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 153-156. DOI：

摘要

目的: 探寻艾滋病及人类免疫缺陷病毒携带(HIV/AIDS)患者尿液的代谢组变化

探讨代谢组学方法在预防和延缓HIV病毒感染者病程进展研究中的应用前景。方法: 运用液质联用技术(LC-MS)

检测55例HIV/AIDS患者和20例健康人的尿液代谢成分

结合主成分分析(PCA)和t检验分析技术

分析HIV/AIDS患者尿液的特异性代谢物质(或群谱)。结果: HIV/AIDS患者组与健康对照组经代谢组学的方法在尿液代谢轮廓上得到了良好区分

发现了10个可能存在的潜在生物学标记物。结论: 代谢组学的研究方法可以将HIV/AIDS患者与健康人进行良好的区分

综合代谢标记物变化趋势构成了HIV/AIDS的代谢特征

代谢组学的方法在预防和延缓HIV病毒感染者病程进展的研究中将有很好的应用前景。

Abstract

Objective: To investigate human immunodeficiency virus(HIV/AIDS) in urine of patients with metabolic changes and to explore future application value of metabonomics technique in research of preventing and delaying the acquired immunodeficiency syndrome. Method: Using liquid chromatography coupled to mass spectrometry (LC-MS)

urine metabolic components in 55 HIV/AIDS patients and 20 healthy human beings were studied by metabonomics method

and combined with principal component analysis (PCA) and t test analysis technology

the specific metabolic substances (or group spectrum)were analyzed. Result: The urine metabolic profiles in the two groups showed differences with 10 potential biological markers. Conclusion: From the metabonomics method

HIV/AIDS patients and healthy people can be well differentiated. Comprehensive metabolic markers indicate HIV/AIDS metabolic characteristics. Metabonomics approach in the study of prevention and delay of HIV virus infection will have good prospects.

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Related Institution

Deng Zhongjia Inheritance Studio，Chengdu University of TCM

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School of Chinese Medicine，Fujian University of TCM

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