An Experimental Study on the Effect of Gansui Banxia Decoction with Different Proportions of KANSUI RADIX and GLYCYRRHIZAE RADIX ET RHIZOMA in Malignant Ascites Rats

WANG Xi; ZHONG Gan-sheng; WANG Hong-lei; LIU Hai-yan; LI Yi-wen; LIU Jia; OU Li-na; CHEN Shao-hong

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An Experimental Study on the Effect of Gansui Banxia Decoction with Different Proportions of KANSUI RADIX and GLYCYRRHIZAE RADIX ET RHIZOMA in Malignant Ascites Rats

更新时间：2024-01-04

- An Experimental Study on the Effect of Gansui Banxia Decoction with Different Proportions of KANSUI RADIX and GLYCYRRHIZAE RADIX ET RHIZOMA in Malignant Ascites Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 4, Pages: 177-181(2013)
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- Published：2013
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WANG Xi, ZHONG Gan-sheng, WANG Hong-lei, et al. An Experimental Study on the Effect of Gansui Banxia Decoction with Different Proportions of KANSUI RADIX and GLYCYRRHIZAE RADIX ET RHIZOMA in Malignant Ascites Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 177-181.
DOI：

WANG Xi, ZHONG Gan-sheng, WANG Hong-lei, et al. An Experimental Study on the Effect of Gansui Banxia Decoction with Different Proportions of KANSUI RADIX and GLYCYRRHIZAE RADIX ET RHIZOMA in Malignant Ascites Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 177-181. DOI：

摘要

目的: 通过甘遂与甘草不同比例配伍的甘遂半夏汤对腹水模型大鼠生物效应影响的实验研究

筛选甘遂与甘草反药配伍起效的配比条件。方法: 将甘遂与甘草按照2因素7水平的均匀设计原则设置不同配伍比例

实验分为正常组、模型组、甘遂半夏汤中甘草与甘遂配比1组(10.40 g:1.17 g)、配比2组(6.94 g:2.23 g)、配比3组(13.87 g:0.05 g)、配比4组(3.47 g:0.39 g)、配比5组(0.21 g:1.56 g)、配比6组(20.80 g:0.78 g)、配比7组(17.34 g:1.94 g)以及呋塞米组(0.004 2 g·kg-1)。观察甘遂与甘草不同配比的甘遂半夏汤对癌性腹水模型大鼠尿量、腹水量、腹水肿瘤坏死因子(TNF-α)、血管内皮生长因子(VEGF)的影响。数据采用中药组方优化软件对生物效应指标进行甘遂与甘草配比的优化分析。结果: 配比1组较模型组能增加腹水大鼠的尿量(P<0.05);配比6

7组降低腹水TNF-α

VEGF水平(P<0.05)。结论: 经过中药组方优化软件分析

醋甘遂与炙甘草以1:15配伍的甘遂半夏汤可能有较好的利水及抗细胞因子作用。

Abstract

Objective: To investigate the effect of Gansui Banxia decoction with different proportion of KANSUI RADIX and Gansui and GLYCYRRHIZAE RADIX ET RHIZOMA in malignant ascites rats

and then find out the compatibility proportion when it works. Method: We set up seven matched groups according to the principle of uniform design(two factors seven levels) compared with normal

model

positive group. At the end of experiment

we measured urine volume with the cylinder

caculated ascite fluid volume through differential value of the body weight of rats with or without ascites

and determined the content of tumor necrosis factorα(TNF-α) and vascular endothelial growth factor (VEGF) in ascites by radioimmunoassay. The data statistic analysis was processed by analysis of variance (ANOVA) in combination with optimized formula soft. Result: Matched group1 could increase urine output(P<0.05)

and matched group 6

group 7 could decrease the content of TNF-α and VEGF(P<0.05). Conclusion: When the ratio is 15: 1 in compatibility of gansui and gancao

it could increase urine output

and inhibit cytokine in malignant ascites.

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