Optimization of Clarification Technology of Yilingjing Oral Liquid
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Optimization of Clarification Technology of Yilingjing Oral Liquid
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 24, Pages: 45-48(2012)
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Published:2012
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GU Zhi-xin, XIA Xin-hua, ZHU Li, et al. Optimization of Clarification Technology of Yilingjing Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 45-48.
DOI:
GU Zhi-xin, XIA Xin-hua, ZHU Li, et al. Optimization of Clarification Technology of Yilingjing Oral Liquid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 45-48.DOI:
Optimization of Clarification Technology of Yilingjing Oral Liquid
Objective:To optimize flocculation clarification technology conditions of Yilingjing oral liquid by chitosan. Method: Taking absorbance and retention rate of stilbene glucoside as evaluation indicators
influence of the mass concentration of extraction liquid
chitosan dosage
pH
temperature
stirring speed
stirring time and other factors on flocculation effect were investigated.Based on single factor test
orthogonal design was selected to optimize flocculation technology with the mass concentration of extraction liquid
chitosan dosage
flocculation temperature as factors.Flocculation clarification method and alcohol sedimentation were compared. Result: Optimal clarification procedure condition was that the concentration of materials-extraction solution 0.25 g·mL-1
the adding dosage of chitosan of 1.2 mL·g-1
flocculation temperature of 60 ℃
pH of 5.0-5.5
stirring speed of 300 r·min-1 and stirring time of 10 min. Conclusion: Chitosan flocculation method could be used as clarification technology of Yilingjing oral liquid
which could substitute ethanol precipitation method.