Objective:To observe the effects of ethyl acetate extraction from Gastrodia elata on the neuroplasticity of rat cerebral ischemia injury model. Method: Sprague-Dawley rats were randomly divided into sham-operation group

model group and ethyl acetate extraction from G. elata group(ethyl acetate extraction group

7.29 g·kg-1). The rat models of middle cerebral artery occlusion were replicated 0.5 h later after the last dose of continuous oral administration of drug on the 7th day and keep administration of drug for another 7 days. Statistic data were collected on death rate of model on 7th day

as well as neurological behavior and expression of GAP-43 at specified time point. Result: Compared with the sham-operation group

the death rate and neurological syndromes of model group were markedly increased and the hanging wire and expression of GAP-43 were significantly decreased. Compared with the model group

the death rate and neurological syndromes of the ethyl acetate extraction group were significantly decreased and the hanging wire and expression of GAP-43 were significantly increased (P<0.05

P<0.01). Conclusion: The results suggest that the ethyl acetate extraction from G. elata can improve the neuroplasticity of cerebral ischemia injury model rat.