Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat
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Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 21, Pages: 145-148(2012)
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Published:2012
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SONG Yi-jun, LIU Xiao-ting, FENG Li-li, et al. Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 145-148.
DOI:
SONG Yi-jun, LIU Xiao-ting, FENG Li-li, et al. Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 145-148.DOI:
Pharmacokinetic Study of Paeonol in Liver Cancer Model Rat
Objective: To establish a sensitive ultraperformance liquid chromatography(UPLC) method for determining the plasma concentration of paeonol in liver cancer model rat and to evaluate its pharmacokinetic characteristics. Method: Rats were divided into three groups
a single ig dose of 259.2
194.4
129.6 mg·kg-1 paeonol was given respectively.Paeonol was separated on a C18 column with methanol:water(70: 30) as mobile phase.The plasma concentration of paeonol was determined and its pharmacokinetic parameters were calculated by using WinNonlin 5.2.1. Result: The linear range of the method for paeonol was 0.323-41.4 mg·L-1.The plasma concentration-time course showed two compartment model
with the increased dose
AUC
Cmaxhas a significant increase
while Tmax
T1/2β
CL have no significant change. Conclusion: The UPLC method for determining paeonol concentration in plasma is simple
rapid
sensitive and suitable for pharmacokinetic study. There are some differences between pharmacokinetic parameters in liver cancer model rats with different dose of paeonol.
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