Effects of Anti-radiation Pneumonia Decoction on Immune Function in Rats with Radiation-induced Pulmonary Injury
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Effects of Anti-radiation Pneumonia Decoction on Immune Function in Rats with Radiation-induced Pulmonary Injury
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 24, Pages: 248-251(2012)
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Published:2012
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CHEN Bu-you, Wang Wei, XIAO Ming-bing, et al. Effects of Anti-radiation Pneumonia Decoction on Immune Function in Rats with Radiation-induced Pulmonary Injury[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 248-251.
DOI:
CHEN Bu-you, Wang Wei, XIAO Ming-bing, et al. Effects of Anti-radiation Pneumonia Decoction on Immune Function in Rats with Radiation-induced Pulmonary Injury[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 248-251.DOI:
Effects of Anti-radiation Pneumonia Decoction on Immune Function in Rats with Radiation-induced Pulmonary Injury
Objective:To explore the effects of anti-radiation pneumonia decoction (ARPD) on immune function in the rats with radiation-induced pulmonary injury. Method: SD rats were randomly divided into four groups: normal control group (group A)
model group (group B)
dexamethasone treatment group (group C) and ARPD treatment group (group D). Rats in group B
C and D were exposed to 6 MV X-ray at a dose of 20 Gy thoracically. After X-ray exposure group C and D were treated with dexamethasone (1.5 ×10-3 g·kg-1·d-1) and ARPD (35 g·kg-1·d-1) respectively by gastrogavage one time a day. The rats in group A and B were gavaged with equal volume 0.9% sodium chloride. The rats were sacrificed at days 7
15
30
50 after X-ray exposure. Pathological changes in spleen tissues were observed and the index numbers of thymus and spleen
T-cell subgroups of peripheral blood
serum hemolysin level
phagocytotic rates of macrophage in abdominal cavity were detected respectively. Result: The pathological changes in group D were slighter and recovered sooner than those in other groups exposed to X-ray. After 50 days
the thymus and spleen indexes
CD3+
CD4+
CD8+
hemolysin levels
phagocytotic rates of macrophage in group D were higher than that in group B and C (P<0.05). Conclusion: ARPD can improve the immune function in the rats with radiation-induced pulmonary injury.
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