Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma
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Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 3, Pages: 265-268(2013)
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Published:2013
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XING Gui-hua, LIU Yu-zhang, ZOU Yu, et al. Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 265-268.
DOI:
XING Gui-hua, LIU Yu-zhang, ZOU Yu, et al. Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 265-268.DOI:
Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma
Objective:In order to evaluate the effect of developmental toxicity of offspring pregnant rats treated with Curcumae Rhizoma. Method: Wistar female rats were randomized into normal group and blood-stasis model group. A model of blood stasis model in rats by injecting adrenalin and being immersed in ice water was used. The rats were mated and pregnant rats of two groups were randomized into the low
medium and large dose sub-groups and control group.Curcumae Rhizoma were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0
1.4
2.8
5.6 g·kg-1. Physical development and neurobehavioral function were examined. Result: There was a difference of neurobehavioral function toxicity induced by Curcumae Rhizoma between normal and blood-stasis pregnant rats. Compared with the blank group
the pass time of cliff avoidance test and negative geotaxis reflex of normal rats delayed significantly. We could not find any significant changes in that of blood-stasis rats. Conclusion: Neurobehavioral toxicity of offspring of the blood-stasis pregnant rats to Curcumae Rhizoma is weaker than that of the normal pregnant rats
confirmed the rationality of evaluating the toxicity of Chinese medicines based on TCM syndrome theory.
Developmental Toxicity of Offspring Induced by Exposure Pregnant Rats to Curcumae Rhizoma
Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma
Screening of Antidepressant Active Components from Curcumae Rhizoma and Its Mechanism in Regulating Nrf2/GPX4/GSH Pathway
Grading of Seed Rhizoma for Curcuma phaeocaulis and Its Effect on Plant Growth, Yield and Quality of Medicinal Materials
Phenols and Organic Acids Constituents in Water Decoction of Curcumae Rhizoma-Sparganii Rhizoma Herbal Pair and Single Herb
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XING Gui-hua
LIU Yu-zhang
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ZHANG Chun
NIU Ying-cai
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GAO Zhi-ying
FAN Li
Related Institution
Institute of Medicine,Qiqihaer Medical College,Qiqihaer
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Key Laboratory of Pharmacodynamics and Safety Evaluation,Health Commission of Jiangxi Province,Nanchang Medical College
Jiangxi Guxiang Jinyun Comprehensive Health Industry Co. Ltd.
State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources,Key Laboratory of Standardization of Chinese Herbal Medicine,College of Pharmacy,Chengdu University of Traditional Chinese Medicine