Effect of Baiyu Lianyu Mixture on Diabetes in Mice
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Effect of Baiyu Lianyu Mixture on Diabetes in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 20, Pages: 278-280(2012)
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Published:2012
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DENG Qi-wei, XU Bu-hai, CHEN Wen, et al. Effect of Baiyu Lianyu Mixture on Diabetes in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 278-280.
DOI:
DENG Qi-wei, XU Bu-hai, CHEN Wen, et al. Effect of Baiyu Lianyu Mixture on Diabetes in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 278-280.DOI:
Effect of Baiyu Lianyu Mixture on Diabetes in Mice
Objective:To study the therapeutic effect of Baiyu Lianyu mixture (BYLY) on diabetes. Method: The mice model of diabetes was induced by intravenous injection of streptozotocin.The diabetes mice were divided into model group
BYLY high dose group (6.0 g·kg-1)
BYLY middle dose group(3.0 g·kg-1)
BYLY low dose group(1.5 g·kg-1
ig) and phenformin group. The drugs were given orally. Blood sugar
glucose tolerance and oxygen-derived free radicals were observed. Result: Compared to the model group
the concentration of fasting blood sugar of the BYLY groups was decreased obviously (P<0.05
P<0.01)
the glucose tolerance increased obviously (P<0.05
P<0.01).The activity of superoxide dismutase (SOD) and glutathione peroxidase(GSH-Px) increased (P<0.01)
malondialdehyde (MDA) decreased obviously (P<0.05
P<0.01). Conclusion: BYLY shows the effects of decreasing blood sugar
raising glucose tolerance and improving metabolism turbulence of oxygen-derived free radicals on diabetes.