The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever

QU Fei; CUI Yan-ru; XU Jing; XU Guo-liang; HUANG Li-ping; YU Ri-yue

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The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever

更新时间：2024-09-23

- The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 184-187(2013)
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- Published：2013
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QU Fei, CUI Yan-ru, XU Jing, et al. The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 184-187.
DOI：

QU Fei, CUI Yan-ru, XU Jing, et al. The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 184-187. DOI：

摘要

目的: 观察麻杏石甘汤对内毒性发热SD大鼠的体温及血浆前列腺素E2(PGE2)水平的影响

并探讨其量效关系。方法: 将66只大鼠随机分为11组

空白对照组

模型组

剂量1组~剂量9组

每组6只

空白对照组尾静脉注射生理盐水

另10组均采用尾静脉注射内毒素的方法制成发热大鼠模型

分别灌胃相应量生理盐水或麻杏石甘汤。观察比较各组体温和6.0 h体温反应指数(TRI6.0)变化

并测定血浆PGE2水平。结果: 与模型组相比

麻杏石甘汤剂量1至剂量9能明显降低发热大鼠的最大温差(ΔTmax)和TRI6.0

麻杏石甘汤存在量效关系

且降温效应为多波折曲线。此外

麻杏石甘汤能剂量依赖性降低血浆PGE2水平。结论: 不同剂量麻杏石甘汤对内毒素性发热SD大鼠的解热作用为多波折量效关系。

Abstract

Objective:To investigate on temperature and prostaglandin E2(PGE2) contents in plasma of rats with endotoxic fever in Maxing Shigan Tang

and found the dose-effect relationship. Method: Sixty-six rats were randomly divided into 11 groups

of which with 6: control group

model group

dose 1-dose 9 groups. The control group was injected normal saline

the other group with endotoxin; dose groups were administrated with Maxing Shigan Tang of different doses. ΔTmax and thermal response index(TRI) were observed. The levels of plasma PGE2 was determined. Result: Compared with control group

dose 1-dose 9 group could depress ΔTmax and TRI significantly. The effect had dose-effect relationship and showed many twists and turns. In addition

Maxing Shigan Tang could lower the level of PGE2 with dose-effect. Conclusion: Different doses of Maxing Shigan Tang have antipyretic effect of dose-effect relationship for the many twists and turns to fever rats.

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Related Author

YU Ri-yue1

HUANG Li-ping1

XU Guo-liang3

XU Jing3

CUI Yan-ru2

QU Fei1

HUANG Lu-qi

Yang Qing

Related Institution

Department of Pharmacology,Jiangxi University of Traditional Chinese Medicine

江西中医学院基础医学院生理学教研室

江西中医学院现代中药制剂教育部重点实验室

Shandong University of Traditional Chinese Medicine,Ji’nan

Depatment of Pharmacology,Jiangxi University of Traditional Chinese Medicine

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