Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate

FU Yan-li; WAN Hong-jiao; ZHU Jin-hua; MA Guang-qiang

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Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate

更新时间：2024-01-04

- Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 173-175(2012)
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- Published：2012
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FU Yan-li, WAN Hong-jiao, ZHU Jin-hua, et al. Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 173-175.
DOI：

FU Yan-li, WAN Hong-jiao, ZHU Jin-hua, et al. Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 173-175. DOI：

摘要

目的: 探讨温胆汤对精神分裂症模型大鼠脑组织中神经胶质细胞连接蛋白(Cx43) mRNA的影响。方法: 将健康的SD大鼠50只随机分为5组:正常组(A)、模型组(B)、温胆汤高、中、低剂量组(C

E组

剂量为生药40

10 g·kg-1)。A

B组生理盐水ig

E组温胆汤ig

1次/d

21 d后

按照0.6 mg·kg-1一次性ip地卓西平马来酸盐(MK-8O1)建立拟精神分裂症模型

然后行为学观察3 d

处死大鼠。应用逆转录聚合酶链式反应(RT-PCR)法

检测大鼠Cx43 mRNA的表达量。结果: 模型组Cx43 mRNA的表达量低于正常组

有显著性意义(P<0.05);温胆汤3个剂量组Cx43 mRNA的表达量明显高于模型组

有显著性意义(P<0.05)。结论: 温胆汤能够增强精神分裂症模型大鼠脑组织中Cx43 mRNA的表达。

Abstract

Objective:To study the effect of Wendan decoction on connexin 43(Cx43) mRNA expression in brain tissue of rats with schizophrenia. Method: Fifty SD rats were divided five groups by random

including normal group(A)

model group(B)

Wendan decoction high-dosage group(C)

medium-dosage group(D) and low-dosage group(E)

respectively. The A and B groups were given normal saline and the C

E groups were given Wendan decoction(40

10 g·kg-1) every day

which lasted for 21 days. Dizocilpine maleate(MK-801) 0.6 mg·kg-1 was ip given to establishthe rat schizophrenic model. Then rat behaviors were observed for 3 days all rats were sacrificed. Then RT-PCR method was used to detect Cx43 mRNA expression in the nervecells of the every group rats. Result: The Cx43 mRNA expression of group B was lower than that of group A (P<0.05).And the Cx43 mRNA expression of group C

D and E was rose compared with that of group B(P<0.05). Conclusion: Wendan decoction can reinforce the expression of Cx43 mRNA in the brain tissue of rats with schizophrenia.

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