Objective:To evaluate the clinical efficacy of traditional Chinese medicine(TCM) dietary supplements (Shenqi Jianpi decoction) combined with TP (paclitaxel plus cisplatin) chemotherapy in the treatment of advanced ovarian cancer. Method: Randomly divided the 86 patients into chemotherapy group and TCM dietary supplements combined with chemotherapy group. The chemotherapy group patients were treated with TP chemotherapy

and no did not accept drug treatment after chemotherapy; on the above basement

the TCM dietary supplements combined with chemotherapy group patients were given TCM dietary supplements (Shenqi Jianpi decoction) after the second day chemotherapy

until the next cycle chemotherapy. The life quality after 1 and 2 year’s treatment

and the follow-up 3 year’s death and transfer situation was observed

and the immune indexes of T lymphocyte subsets and natural killer(NK) cells in peripheral blood were detecte. Result: The life quality of TCM dietary supplements combined with chemotherapy group patients after 1 year treatment was obviously higher than the chemotherapy group

and there was significant difference; the life quality after 2 years had no significant difference (P＞0.05); the death rate and transfer rate after 3 years were lower than the pure chemotherapy group

and there was significant difference compared with the pure chemotherapy (P＜0.05).The CD4+ was increased significantly

the CD8+ was decreased significantly

the CD4+/CD8+was increased significantly

and the activity of NK cell was increased significantly

and there was significant difference (P＜0.05) compared with the pure chemotherapy group after treatment. Conclusion: The activity of immune cells in peripheral blood of the advanced ovarian cancer after the treatment of TCM dietary supplements combined with chemotherapy was improved

the immunity was enhanced

and the patient ’s life quality was improved

the life prolonged

and the death rate and transfer rate decreased. The clinical efficacy was exact and patients had good tolerance

and there was clinical promotion.