Optimization of Preparation Technology and Investigation of  Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules

DOU Peng; ZHANG Hua; ZHANG Wen

您当前的位置：

首页 >

文章列表页 >

Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules

更新时间：2024-01-04

- Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 24, Pages: 49-52(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
DOU Peng, ZHANG Hua, ZHANG Wen. Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 49-52.
DOI：

DOU Peng, ZHANG Hua, ZHANG Wen. Optimization of Preparation Technology and Investigation of Release Mechanism of Sinomenine Hydrochloride- Polyvinyl Alcohol Microcapsules[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 49-52. DOI：

摘要

目的: 优选盐酸青藤碱聚乙烯醇(SM-PVA)微胶囊的制备工艺

并考察其表征及体外释放性能。方法: 以载药量为指标

选取乳化剂用量、搅拌速度、戊二醛体积分数及油相环己烷用量为考察因素

采用W/O/W复乳界面聚合法制备SM-PVA微胶囊

通过正交试验优选SM-PVA微胶囊的制备工艺;采用紫外分光光度法测定载药量

扫描电镜观察SM-PVA微胶囊形貌

粒径分析仪表征胶囊粒径分布情况

同时考察SM-PVA微胶囊的体外释放性能。结果: 优选的制备工艺为乳化剂用量7%

搅拌速度600 r·min-1

戊二醛用量25%

环己烷10 mL

载药量6.23%;制备的SM-PVA微胶囊平均粒径约16 μm

呈均匀分散、表面光滑的球形。制得的SM-PVA微胶囊在模拟胃液和肠液中都表现出较好的缓释作用。结论: SM-PVA微胶囊可成为中药盐酸青藤碱的一种新型给药系统。

Abstract

Objective:To optimization preparation technology of sinomenine hydrochloride-polyvinyl alcohol (SM-PVA) microcapsules

and investigate its characterization and in vitro release performance. Method: With drug loading as index

the amount of emulsifier

stirring speed

volume fraction of glutaraldehyde and dosage of cyclohexane(oil phase) were chosen as factor

SM-PVA microcapsules was prepared byW/O/W multiple emulsion interfacial polymerization method

preparation technology of SM-PVA microcapsules was optimized by orthogonal test;drug loading was determined by UV spectrophotometric

morphology of SM-PVA microcapsules was scanned by electron microscopy

particle size of SM-PVA microcapsules was charactered by particle size analysis instrument

and in vitro release performance was investigated. Result: Optimum preparation technology was:7% emulsifier

stirring speed 600 r·min-1

volume fraction of glutaraldehyde 10 mLand 25% cyclohexane

drug loading 6.23%;Average particle size of SM-PVA microcapsules 16 μm

it showed uniform dispersion and smooth surface of spherical.These prepared SM-PVA microcapsules showed good sustained release in simulated gastric and intestinal fluid. Conclusion: SM-PVA microcapsules could be a novel drug delivery system of sinomenine hydrochloride from Chinese materia medica.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Electroporation on Percutaneous Permeation of Sinomenine Hydrochloride

Pharmacokinetics Study on Sinomenine Hydrochloride in Rats with Administration route of Intramscular Injection by Using Microdialysis Method

Preparation and Drug Release Behavior in vitro of Medicine Loaded PVA Fibrous Membrane

Effect of Gel Material Ratio on Percutaneous Absorption of Basil Oil Transdermal Gel

Development of Release Methods in Lipid Nanoparticles Drug Delivery System

Related Author

Jian TENG

Tong-tong SUN

Li XU

Ping QIU

Qing WANG

Sen YAN

ZHOU Li-ling

WANG Li-sheng

Related Institution

State Key Laboratory of Fine Chemicals，School of Chemical Engineering， Dalian University of Technology

Hunan Zhengqing Pharmaceutical Group Co. Ltd.

Dalian Kexiang Technology Development Co. Ltd.

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰