Influence of Bansizuo Prescription on Nitric Oxide and Gastrin in Rats with Gastric Ulcer

CHEN Jian-zhang; CHEN Wen; YU Qing; XU Bu-hai; WANG Xiao-ping; ZHOU Yu-ping

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Influence of Bansizuo Prescription on Nitric Oxide and Gastrin in Rats with Gastric Ulcer

更新时间：2024-01-04

- Influence of Bansizuo Prescription on Nitric Oxide and Gastrin in Rats with Gastric Ulcer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 21, Pages: 240-243(2012)
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- Published：2012
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CHEN Jian-zhang, CHEN Wen, YU Qing, et al. Influence of Bansizuo Prescription on Nitric Oxide and Gastrin in Rats with Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 240-243.
DOI：

CHEN Jian-zhang, CHEN Wen, YU Qing, et al. Influence of Bansizuo Prescription on Nitric Oxide and Gastrin in Rats with Gastric Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(21): 240-243. DOI：

摘要

目的: 观察半四左方对大鼠实验性胃溃疡和血清胃泌素(GAS)和一氧化氮(NO)的影响

探讨半四左方抗胃溃疡损伤的作用机制。方法: 采用束缚水浸应激法和醋酸法建立大鼠胃溃疡模型。经半四左方干预后(含生药6.3 g ·kg-1

水浸应激法造模前连续ig 15 d

醋酸法造模后连续ig 5 d

测定水浸应激溃疡大鼠溃疡指数、醋酸型溃疡大鼠溃疡面积、以及2个溃疡模型大鼠血清GAS

NO水平。结果: 半四左方可显著降低束缚水浸应激溃疡大鼠溃疡指数(P<0.01)和醋酸型溃疡大鼠溃疡面积(P<0.01)

并能降低胃溃疡大鼠异常升高的血清GAS

NO(P<0.01)

使之恢复至接近正常水平。结论: 半四左方具有明显的抗胃溃疡作用

其作用机制可能与其影响大鼠血清GAS和NO水平有关。

Abstract

Objective: To investigate the influence of Bansizuo prescription on nitric oxide and gastrin of blood serum in experimental rats with gastric ulcer and to search out the possible mechanism of cure gastric ulcer Method: The experimental gastric ulcer model in rats was induced by acetic acid and water immersing excitability. After be intervened with Bansizuo prescription

the ulcer index was measured for the model rats induced by water immersing excitability

the ulcer area was determined for the rats of acetic acid model

and nitric oxide and gastrin in serum were evaluated for the rats of two models. Result: Bansizuo prescription could reduce obviously the ulcer area in rats of acetic acid model and the ulcer index in rats of aqueous extract excitability model (P<0.01). It could bring down the nitric oxide and gastrin in serum of experimental rats to near normal level (P<0.01). Conclusion: Bansizuo prescription can repaire stomach mucosa damage to withstand gastric ulcer

its mechanism maybe related with the influenced in the nitric oxide and gastrin in serum.

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Related Author

BAI Xi-wei

QU Yi

JIANG Ning

SUN Yun-feng

LIN Shu-ru

CAI Li-ping

ZHENG Hong-xin

ZHOU Xue-wen

Related Institution

The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine

School of Pharmacy， Academy of Chinese Medical Sciences， Henan University of Chinese Medicine

Pingxiang Hospital of Traditional Chinese Medicine

Baixiang Country Central Hospital

Shijiazhuang Medical College

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