Objective:To observe effects of Jiangtang Xiaozhi(JTXZ) tablets on expression of insulin receptor β(InsRβ) and insulin receptor substrate-1(IRS-1) in KK-Ay transgenic mice model of diabetes mellitus (DM). Method: KK-Ay transgenic mice were used and fed with high-fat diet to induce hyperglycemia as a model of DM obesity. The C57mice with same age of KK-Ay transgenic mice were used as a control group. Thereafter

Fifty-five mice with DM obesity were divided into 5 groups (n=11) including model group without any treatment

pioglitazone hydrochloride tablets treatment group as a positive control group

and JTXZ tablets groups at high

middle and low treatment doses

and were continuously given JTXZ tablets by intragastric administration for 8 weeks. All mice were sacrificed after treatment of 8 weeks. The pathology examination of abdominal salivary gland was performed. The expression of InRβ and IRS-1 were deteced

respectively. Result: In the JTXZ tablets treatment group

compared with that in KK-Ay transgenic mice model with DM obesity

the pancreatic pathological changes were ameliorated significantly. Expression of InRβ and IRS-1 were increased in each treatment group by JTXZ tablets

respectively. Conclusion: JTXZ tablets have obvious effects of increasing levels of InRβ and IRS-1 in KK-Ay transgenic mice model with DM obesity.