Objective:To observe the effect of Sini decoction(it consist of Radix Aconiti Praeparata

Rhizoma Zingiberis and Radix Glycyrrhizae Preparata) on high density lipoprotein cholesteol(HDL-CH)

low density hpoprotein cholested( LDL-CH) and apolipoprotein (Apo)-A

B on the hyperlipidemia (HLP) combined with atherosclerosis in rabbits. Method: The rabbits were fed with high fat food everyday and injected with BSA

egg-white protein to make HLP combined AS modle

then randomized them into model group and three dose groups treated by Sini decoction(high

medium and low) and Atorvastatin respectively. Colorimetric assay method was used to determine LDL-CH

HDL-CH levels and electrophoresis wa used to measure levels of apolipoprotein A and B changes. Result: Sini decoction high-dose group

decreased LDL and Apo-B level compared with the model group (P<0.05). Sini decoction hihg dose group incresed HDL

Apo-A content

HDL/LDL and Apo-A/Apo-B ratio compared with the model group (P<0.01). Conclusion: Sini decoction can increase HDL and Apo-A content

reduce the content of LDL and Apo-B

which may be one of the mechanisms of the anti-hyperlipidemia with atherosclerosis rationale by Sini decoction.