Preparation and Release Evaluation of Extract Stomach Floating Retention Sustained-Release Tablet
|更新时间:2024-01-04
|
Preparation and Release Evaluation of Extract Stomach Floating Retention Sustained-Release Tablet
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 22, Pages: 25-29(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
DU Qian, YIN Xiao-xing, TANG Dao-quan, et al. Preparation and Release Evaluation of Extract Stomach Floating Retention Sustained-Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 25-29.
DOI:
DU Qian, YIN Xiao-xing, TANG Dao-quan, et al. Preparation and Release Evaluation of Extract Stomach Floating Retention Sustained-Release Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 25-29.DOI:
Preparation and Release Evaluation of Extract Stomach Floating Retention Sustained-Release Tablet
and investigate its in vitro release property. Method: With floating time and floating start time as indexes
single factor test was used to investigate sustained framework material
start floating agent
the amount of HMPC and octadecanol;With composite score of cumulative release rate
floating start time and floating time as index
the amount of HPMC K4M
PVPP
octadecanol and effervescent were selected as factors
orthogonal test was designed to optimize prescription and preparation technology
and in vitro release mechanism of this sustained-release tablet was investigated. Result: Optimum prescription:mass fraction of HPMC K4M
PVPP
G. biloba extract
octadecanol and effervescent were 30%
2%
20%
48%
4%
respectively;with MCC as diluent agent to fill quality.Release dynamical model of G. biloba extract stomach floating retention sustained-release tablet was coincident with Higuchi equation. Conclusion: Prepared sustained-release tablet had good appearance
compressibility and release property
release mechanism of it was dual function of diffusion and dissolution.