Clinical Effect Observation of Fuzheng Xiaoai Mixture Combined with Chemotherapy of GP Regimen in Treating Patients with Advanced Non-samll Cell Lung Cancer

DENG Xiao-ming; DU Ji-ying; ZENG Chen; GU Zhao-sen; DU Yan-jun; WANG Shu-ling

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Clinical Effect Observation of Fuzheng Xiaoai Mixture Combined with Chemotherapy of GP Regimen in Treating Patients with Advanced Non-samll Cell Lung Cancer

更新时间：2024-01-04

- Clinical Effect Observation of Fuzheng Xiaoai Mixture Combined with Chemotherapy of GP Regimen in Treating Patients with Advanced Non-samll Cell Lung Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 328-331(2012)
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- Published：2012
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DENG Xiao-ming, DU Ji-ying, ZENG Chen, et al. Clinical Effect Observation of Fuzheng Xiaoai Mixture Combined with Chemotherapy of GP Regimen in Treating Patients with Advanced Non-samll Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 328-331.
DOI：

DENG Xiao-ming, DU Ji-ying, ZENG Chen, et al. Clinical Effect Observation of Fuzheng Xiaoai Mixture Combined with Chemotherapy of GP Regimen in Treating Patients with Advanced Non-samll Cell Lung Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 328-331. DOI：

摘要

目的: 观察扶正消癌合剂联合GP(吉西他滨+顺铂)方案治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法: 将60例晚期NSCLC患者随机分为两组各30例。对照组采用GP(吉西他滨1.0 g·m-2

第1

8天静脉滴注;顺铂20 mg·m-2

第1天静脉滴注)方案治疗

治疗组给予GP方案联合扶正消癌合剂(早晚各温服1袋

200 mL/袋)治疗。均21 d为1周期

至少化疗2周期。结果: 治疗组与对照组的有效率分别是23.33%

16.67%

两组差异无统计学意义。但在生活质量评分、免疫功能、中医证候改善、毒副反应发生率及外周血VEGF(血管内皮生长因子)水平的改变差异有统计学意义(P<0.05)。结论: 扶正消癌合剂联合GP方案可以改善晚期非小细胞肺癌患者的生活质量、免疫功能且可以减毒增效。

Abstract

Objective:To observe the clinical efficacy of Fuzheng Xiaoai mixture combined with gemcitabine-ciplatimon(GP) regimen in the treatment of advanced non-small cell lung cancer(NSCLC). Method: Sixty patients with advanced NSCLC were randomized into two groups

each 30 cases. The control group was treated with GP regimen

the treatment group was trea-ted with Fuzheng Xiaoai mixture combined with GP program. A treatment cycle lasted 21 days

at least two cycles. Result: The effective rate was 23.33%

16.67% in the treatment group and the control group

respectively

but there was no significant difference between two groups. But the treatment group has significant differences compared with the control group in the quality of life score

immune function

toxicity and adverse in-cidence

and the change of VEGF levels in peripheral blood (P<0.05). Conclusion: Fuzheng Xiaoai mixture combined with GP program can improve the quality of life in advanced non-small cell lung cancer patients

immune function and can reduce toxicity and increase efficiency.

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