Physicochemical Properties, Pharmacodynamics and Toxicity of Pharmaceutical Mercuric Sulfide

WANG Yi-bo; CHEN Chao-jun; LU Jing-kun; WU Shi-kui; MA Lei; SUN Xiao-yan

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Physicochemical Properties, Pharmacodynamics and Toxicity of Pharmaceutical Mercuric Sulfide

更新时间：2024-01-04

- Physicochemical Properties, Pharmacodynamics and Toxicity of Pharmaceutical Mercuric Sulfide
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 23, Pages: 356-359(2012)
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- Published：2012
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WANG Yi-bo, CHEN Chao-jun, LU Jing-kun, et al. Physicochemical Properties, Pharmacodynamics and Toxicity of Pharmaceutical Mercuric Sulfide[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 356-359.
DOI：

WANG Yi-bo, CHEN Chao-jun, LU Jing-kun, et al. Physicochemical Properties, Pharmacodynamics and Toxicity of Pharmaceutical Mercuric Sulfide[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 356-359. DOI：

摘要

对药用硫化汞的形态结构、理化性质、含量测定及药效毒理学进行了归纳

查阅了国内外文献30篇

探讨了药用硫化汞中汞元素的体内存在形态、体内含量对其毒性的影响。研究发现

朱砂、银朱等药物中的硫化汞为具旋光性的红色结晶

在体外的存在形式通常是不溶于水的Hg2+

还有一部分可溶性的Hg2+

Hg+

含汞药物产生毒性的原因主要是其中的可溶性汞

而主要成分是硫化汞的药物

如朱砂

在肠道中可能以汞与硫各种形式的配合物存在

多硫化汞配合物是其中的一种重要形式

多硫化汞的形式降低了游离汞的含量

毒性降低。药效毒理的研究发现

含汞药物的临床用量一般情况下不会引起中毒。实践表明

通过采取现代分析手段制定相应规范

可以在保证药效的基础上

提高含汞药物的安全性。

Abstract

We summarize species analysis of mercuric sulfide by consulting documents

also discuss how the forms of mercuric sulfide influence on the toxicity and pharmacological function. Recent evidence suggests that mercuric sulfide in cinnabar and vermilion is red crystallization of optical activity

insoluble Hg2+

soluble Hg2+

Hg+are storage forms of mercury sulfide in vitro

and insoluble Hg2+is the main form. The main toxicity of mercuric drugs is caused by soluble mercury. Mercuric sulfide acts as main component of many tradition drugs

these drugs may exist as polysulfide. This existence form will reduce its toxicity. Pharmacological research shows that clinical dosage usually does not cause people poisoned. We should establish standards through modern analysis in order to ensure the safety of mercury-containing drugs.

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Related Institution

Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of TCM

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Department of Pharmaceutics,Hunan University of Chinese Medicine

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Pharmaceutical Preparation Technology and Evaluation Laboratory of Chinese Materia Medica,Hunan University of Chinese Medicine

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