Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol

SUI Rong-yan; WANG Wan-hui; LIAN Lei-fan; LI Hong-yan; LI Xiao; HUANG Zhi-hua; ZENG Jing

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Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol

更新时间：2024-01-04

- Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 175-178(2012)
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- Published：2012
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SUI Rong-yan, WANG Wan-hui, LIAN Lei-fan, et al. Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 175-178.
DOI：

SUI Rong-yan, WANG Wan-hui, LIAN Lei-fan, et al. Anti-oxidation and Anti-inflammation Effect of Genistein on Myocardial Hypertrophy in Rats Induced by Isopropylarterenol[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 175-178. DOI：

摘要

目的:观察染料木素(Gen)对异丙肾上腺素(Iso)所致心肌肥厚大鼠的抗氧化及抑制炎症反应作用。方法:采用背部sc给予Iso1mg·kg-1·d-1

连续10d

建立大鼠心肌肥厚模型。造模第2天

正常对照组及模型组于背部sc给予NS2mL·kg-1·d-1

溶剂对照组给予等体积7%DMSO

Gen组给予等体积的Gen0.03

0.1

0.3μmol·kg-1

连续14d。末次给药后禁食12h

称体重

麻醉

取静脉血

分离血清

取心脏

称左心室质量

计算左心室质量参数;检测血清超氧化物歧化酶(superoxidedismutase

SOD)、髓过氧化物酶(myeloperoxidase

MPO)活性及丙二醛(malondialdehyde

MDA)含量;放射免疫学方法检测心肌组织白细胞介素2(interleukin-2

IL-2)含量。结果:与正常对照组相比

模型组大鼠左心室质量参数明显升高(2.48±0.11)mg·kg-1

P<0.001

血清SOD活性明显降低(128.19±11.20)U·mL-1

P<0.05

血清MDA含量增高(15.81±1.96)mmol·mL-1

P<0.05

血清MPO活性提高(12.22±2.34)U·mL-1

P<0.05

心肌组织IL-2含量增高(11.41±1.08)pg·mgprot-1

P<0.05。染料木素低、中、高剂量明显提高血清SOD活性(160.47±16.01

164.36±9.39

172.03±8.42)U·mL-1

P<0.01

降低血清MDA含量(11.96±2.17

11.72±0.73

10.93±0.52)mmol·mL-1

P<0.05

降低血清MPO活性(9.84±2.03

8.91±2.03

7.51±1.97)U·mL-1

P<0.01

降低心肌组织IL-2含量(9.70±1.81

5.95±3.39

6.33±1.19)pg·mgprot-1

P<0.05。结论:染料木素可通过提高抗氧化能力及抗炎症反应抑制Iso诱导的大鼠心肌肥厚。

Abstract

Objective:To observe the antioxidation and anti-inflammation effect of genistein (Gen) on rat myocardial hypertrophy caused by isopropylarterenol (Iso). Method:The rat myocardial hypertrophy model was reproduced through hypodermic injection which lasted 10 days at back skin with Iso

1 mg·kg-1·d-1. Once the model was succesfully made

rats were administrated with corresponding doses of Gen

DMSO or normal saline through hypodermic injection from the second day

and the process lasted 14 days. After the last administration

the rats were lasted overnight and samples of blood and heart were collected under anesthesia status. The indexes of left ventricle were calculated

the activity of superoxide dismutase(SOD)

myeloperoxidase(MPO) and the concentration of malondialdehyde(MDA) in serum were detected

and interleukin-2(IL-2) in myocardial tissue was investigated with radioimmunity kits. Result:In model group

there was a marked increase in the left ventricle index

the activity of SOD in the serum was markedly decreased

the content of MDA and the activity of MPO in the serum were increased

the level of IL-2 in myocardial tissue of rats was increased. Treatment with Gen significantly increased the activity of SOD in the serum

decreased the content of MDA and the activity of MPO in the serum

reduced the level of IL-2 in myocardial tissue. Conclusion:Gen has antioxidation and anti-inflammation effect on the myocardial hypertrophy caused by Iso.

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