Objective: To explore the antioxidative and antitumor effects of buckwheat flower and leaf extracts on S180 tumor-bearing mice. Method: The mice S180 tumor model was established; the model groups were divided into extraction of buckwtheal flower and leaf(EBFL)-low group (200 mg·kg-1)

EBFL-high group (400 mg·kg-1)

and combined with cydophosphamide(CTX

25 mg·kg-1). The solid tumor weight

ascites tumor weight and abdominal circumference growth rate and survival rate were measuredafter administration. glutathione peroxidase(GSH-Px)

superoxide dismutase(SOD) activity and malondialdehyde(MDA) content were determined. Result: After EBFL treatment for 15 d

the symptom of body weight loss was ameliorated and the growth of tumor was inhibited in tumor-bearing mice.EBFL(L

H)treatment could increase the levels of serum GSH-Px (P<0.05

P<0.01) and the activity of SOD in EBFL(H)group was obviously increased (P<0.05) compared with those of control group. The effect was similar to CTX. Compared with control group

the level of MDA was decreased significantly in tumor-bearing mice. Conclusion: EBFL can inhibit the growth of S180 mouse in a certain extent

which may be related to the increasing GSH-Px and SOD activity and decreased MDA content.