Effect of Kuiyangping on Expression of VEGF and Flt-1 mRNA in Gastric Mucosa of Rats with Aspirin-induced Gastric Ulcer Recurrence

ZHAO Kun; ZHAO Hong-ye; NIU Shu-dong; WANG Bin

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Effect of Kuiyangping on Expression of VEGF and Flt-1 mRNA in Gastric Mucosa of Rats with Aspirin-induced Gastric Ulcer Recurrence

更新时间：2024-01-04

- Effect of Kuiyangping on Expression of VEGF and Flt-1 mRNA in Gastric Mucosa of Rats with Aspirin-induced Gastric Ulcer Recurrence
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 20, Pages: 267-269(2012)
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- Published：2012
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ZHAO Kun, ZHAO Hong-ye, NIU Shu-dong, et al. Effect of Kuiyangping on Expression of VEGF and Flt-1 mRNA in Gastric Mucosa of Rats with Aspirin-induced Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 267-269.
DOI：

ZHAO Kun, ZHAO Hong-ye, NIU Shu-dong, et al. Effect of Kuiyangping on Expression of VEGF and Flt-1 mRNA in Gastric Mucosa of Rats with Aspirin-induced Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 267-269. DOI：

摘要

目的: 以非甾体类抗炎药物阿司匹林所致胃溃疡复发大鼠为模型

探讨溃疡平抗胃溃疡复发的机制。方法: 以Okeba改良法复制大鼠实验性胃溃疡

ig阿司匹林制作复发模型

采用RT-PCR法观察溃疡平5.6 g·kg-1

连续ig 14 d对胃溃疡组织血管内皮生长因子(vascular endothelial growth factor

VEGF) mRNA表达的影响。结果: 溃疡平组VEGF mRNA和VEGF受体(Flt-1) mRNA的表达较复发组显著增高(P＜0.01)。结论: 溃疡平可提高胃黏膜中VEGF和Flt-1 mRNA的表达

从而增加黏膜中微血管通透性

将胃内有害物质稀释

并且刺激黏膜中腺体和血管的生成

达到保护胃黏膜的作用。这可能是溃疡平促进胃溃疡愈合

减少其复发的重要机制之一。

Abstract

Objective:To investigate the anti-ulcer recurrence mechanism of Kuiyangping through establishing experimental chronic ulcer model. Method: Okeba modified method was used to establish gastric ulcer model in rats by administering intragastrically with aspirin once a day. Kuiyangping of 5.60 g·kg-1 was administrated for 14 days. The RT-PCR method was used to detect the expressions of vascular endothelial growth factor(VEGF) and its receptor Flt-1 mRNA in the gastric mucosa surrounding ulcer. Result: Kuiyangping could increase the expression of VEGF and Flt-1 mRNA in the gastric mucosa surrounding ulcer (compared with recurrence group

P<0.01). Conclusion: Kuiyangping could decrease the gastric ulcer recurrence induced by aspirin. The effective mechanisms might be related to the enhancement of the expression of VEGF and Flt-1 mRNA

the increase in microvascular permeability

and the promotion of vasculogenesis in the gastric mucosa surrounding ulcer.

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