Preparation of Paclitaxel-loaded Folate-conjugated Hyaluronic Acid Polymeric Micelle

LIU Yan-hua; SUN Jin; WANG Wen-ping; HE Zhong-gui

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Preparation of Paclitaxel-loaded Folate-conjugated Hyaluronic Acid Polymeric Micelle

更新时间：2024-01-04

- Preparation of Paclitaxel-loaded Folate-conjugated Hyaluronic Acid Polymeric Micelle
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 66-69(2012)
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- Published：2012
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LIU Yan-hua, SUN Jin, WANG Wen-ping, et al. Preparation of Paclitaxel-loaded Folate-conjugated Hyaluronic Acid Polymeric Micelle[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 66-69.
DOI：

LIU Yan-hua, SUN Jin, WANG Wen-ping, et al. Preparation of Paclitaxel-loaded Folate-conjugated Hyaluronic Acid Polymeric Micelle[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 66-69. DOI：

摘要

目的:制备叶酸(FA)接枝透明质酸-十八烷基(FA-HA-C18)聚合物胶束

用于包载紫杉醇。方法:通过叶酸活性酯与HA-C18上的羟基反应

制备FA-HA-C18聚合物

采用红外、紫外光谱法鉴定聚合物的结构

并测定叶酸取代度;通过超声法制备FA-HA-C18包载紫杉醇的聚合物胶束

并优化制备工艺

测定载药胶束的平均粒径和Zeta电位。结果:合成了每100个透明质酸分子上接枝6.8个叶酸分子的FA-HA-C18聚合物

制得的FA-HA-C18载药胶束的平均粒径为(191.9±8.7)nm

Zeta电位为-33.3mV。结论:FA-HA-C18聚合物胶束可作为难溶性药物紫杉醇优良的纳米载体材料。

Abstract

Objective:To prepare folate-conjugated hyaluronic acid-octadecyl (FA-HA-C18) polymeric micelle for paclitaxel loading. Method:FA-HA-C18 copolymer was prepared by the reaction of the activated folate ester with the carboxyl group on the hyaluronic acid. The chemical structure was identified by FTIR and UV techniques. The paclitaxel-loaded FA-HA-C18 polymeric micelle was prepared by ultrasonic method

and the preparing process was also optimized. The average particle size and zeta potential of the paclitaxel-loaded FA-HA-C18 micelle were determined. Result:The degree of substitution of folate in FA-HA-C18 copolymer was 6.8%. The average particle size and zeta potential of paclitaxel-loaded FA-HA-C18 polymeric micelles were (191.9±8.7) nm and -33.3 mV

respectively. Conclusion:FA-HA-C18 polymeric micelles could be used as a novel drug delivery system for paclitaxel.

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