Processing Technology and Pharmacodynamics of Hanshuishi
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Processing Technology and Pharmacodynamics of Hanshuishi
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 1, Pages: 191-194(2013)
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Published:2013
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CHEN Zhao-jun, LU Jing-kun, GAO Tian, et al. Processing Technology and Pharmacodynamics of Hanshuishi[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 191-194.
DOI:
CHEN Zhao-jun, LU Jing-kun, GAO Tian, et al. Processing Technology and Pharmacodynamics of Hanshuishi[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 191-194.DOI:
Processing Technology and Pharmacodynamics of Hanshuishi
Objective:To optimize the processing technology of Hanshuishi and obtain the basic pharmacodynamic parameters. Method: An orthogonal experiment of four factors and three levels was conducted to evaluate the Hanshuishi processing technology
and the characters of calcined products and CaCO3 content were used as observation indexes. The animals were divided into model group
100 mg·kg-1 Ranitidine group
360.4 mg·kg-1Jiebai Wan group
334.3 mg·kg-1the Jiebai Wan removed Hanshuishi group
26.1 mg·kg-1 henan Hanshuishi
zejiang Hanshuishi and xinjiang Hanshuishi groups
Pylorus-ligated rat model was applied to observe the effect on gastric juice volume
acidity and pH value of the rats subjected to intragastric administration. Result: The processed traits of Hanshuishi were crisp
white color and powder. The optimum conditions of the Hanshuishi were particle size of powder (20 mesh)
temperature of 1 000℃
time 1.5 h; In addition to the 13th sample produced in Zhejiang
the other Hanshuishi groups and the Jiebai Wan group removed Hanshuishi could significantly decrease the volume
total acidity and 1 h acid excretion of gastric juice of experimental rats and increase pH value; Except of increasing the pH value
Jiebai Wan group had no effect
The efficacy of henan Hanshuishi was optimal and the Zejiang one had a poor performance. Conclusion: Hanshuishi inhibited gastric secretion of rats; moreover
the efficacy of Hanshuishi from different areas has slightly different.
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