Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression

XIAO Wen; LI Cang-xia; XUE Hai-long; JIA Xiu-li

您当前的位置：

首页 >

文章列表页 >

Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression

更新时间：2024-01-04

- Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 278-280(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
XIAO Wen, LI Cang-xia, XUE Hai-long, et al. Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 278-280.
DOI：

XIAO Wen, LI Cang-xia, XUE Hai-long, et al. Zuogui Wan and Anti-despression Wan for Treating 45 Cases Menopausal Women with Depression[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 278-280. DOI：

摘要

目的:探讨左归丸合解郁丸治疗围绝经期妇女抑郁症的临床疗效及作用机制。方法:90例患者随机分为治疗组和对照组各45例。对照组采用盐酸度洛西汀20mg

tid

口服;治疗组

左归丸

口服

9g/次

2次/d;解郁丸

口服

4g/次

3次/d。疗程8周。评价汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数量表(PSQI)

检测血清雌二醇(E2)、促卵泡成熟素(FSH)、促黄体生成素(LH)及血清5-羟色胺(5-HT)。结果:治疗8周后治疗组HAMD及PSQI评分均低于对照组(P<0.01);治疗组E2水平明显升高

高于对照组(P<0.01);两组FSH

LH水平明显降低

治疗组FSH

LH水平低于对照组(P<0.05

P<0.01);两组血清5-HT水平明显升高

治疗组升高幅度不如对照组(P<0.05);治疗组总有效率91.11%

优于对照组的75.55%(P<0.05)。结论:左归丸合解郁丸治疗围绝经期妇女抑郁症有较好的临床疗效

安全性好。

Abstract

Objective:To study the clinical efficacy and mechanism of action for treating menopausal women with depression by Zuogui wan and anti-depression wan. Method:Ninety patients were randomly divided into treatment and control groups (n=45 each). Control group were treated with duloxetine 20 mg

tid

orally. The treatment group was given Zuogui wan

9 g

bid orally and anti-depression wan

4 g

tid

orally

for 8 weeks. The Hamilton Depression Rating Scale (HAMD)

the Pittsburgh Sleep Quality Index Scale (PSQI)

serum estradiol (E2)

follicle-stimulating hormone (FSH)

luteinizing hormone (LH) and serum 5-hydroxy tryptamine(5-HT) were used to evaluate the efficacy. Result:After 8 weeks treatment

HAMD and PSQI scores in the treatment group were lowered compared with those in the control group (P<0.01). In the treatment group

level of E2 was significantly increased

higher than that in the control group (P<0.01). FSH and LH levels in the two groups were significantly lowered. The levels of FSH and LH were significantly lowered in the treatment group compared with those in the control group (P<0.05

P<0.01). Serum 5-HT levels were significantly elevated in the two groups

the level in treatment group was not increased as that much as in the control group (P<0.05). The total effective rate of treatment group(91.11%) was better than that in the control group(75.55%) (P<0.05). Conclusion:Zuogui wan and anti-depression wan are effective and safety for treating menopausal women with depression.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mahoniae Caulis Alkaloids Ameliorate Depression by Regulating Synaptic Plasticity via cAMP Pathway

Characteristic Expression of Multiple Neurotransmitters Oscillation Imbabance in Brains of 1 028 Patients with Depression

Bupleuri Radix Associated Prescriptions Against Depression： A Review

Effect of Zuogui Wan and Yougui Wan on Mitochondrial Biogenesis in BMSCs Through PGC-1α/PPARγ

Effect of Processed Polygonatum cyrtonema in Preventing Depression Induced by Chronic Unpredictable Mild Stress in Female Rats

Related Author

HE Junhui

JIA Chunlian

LAI Kedao

ZHOU Guili

ZHOU Rongfei

LI Yi

LI Dongmei

XIE Jiaxiu

Related Institution

Key Laboratory of Chemistry and Engineering of Forest Products， National Ethnic Affairs Commission， Guangxi Key Laboratory of Chemistry and Engineering of Forest Products/Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products， School of Chemistry and Chemical Engineering， Guangxi Minzu University

Guangxi Key Laboratory of Chinese Medicine Quality Standard， Guangxi Institute of Chinese Medicine and Pharmaceutical Science

Guangxi Medical University

Beijing University of Chinese Medicine

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰