Objective:To study the effect and pharmacological mechanism of Morus alba for trating non-insulin-dependent diabetes mellitus. Method: The KKAy mice were randomly divided into 5 groups: model group

Morus alba high

middle and low dose groups (3

1.5

0.75 g·kg-1) and metformin group (0.4 g·kg-1). Model group and control group animals were administrated with the same volume of tap water. Four weeks later

the contents of fasting plasma glucose (FPG)

fasting plasma insulin (FIns) were observed

and the insulin sensitivity of mice was analyzed. Total RNA was extracted from island cells and the content of TLR2 and TLR4 was evaluated with Real time-PCR method. Result: Morus alba of different doses could obviously decrease the amount of FPG(P<0.05 or P<0.01)

decrease the content of insulin

reinforce the sensitivity of rat to exogenous insulin (P<0.05 or P<0.01) and decrease the expression of TLR2

TLR4 of KKAy mice islet cells. Conclusion: Morus alba had significant effect to decrease FPG and improve the sensitivity to exogenous insulin

its effects may be related to the decrease in expression of TLR2

TLR4 and inhibition of inflammation.