Optimization of Spray Drying Process for Compound Shaji Granules

WU Ri-na; NA Sheng-sang; BAO Le-chaolu

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Optimization of Spray Drying Process for Compound Shaji Granules

更新时间：2024-01-04

- Optimization of Spray Drying Process for Compound Shaji Granules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 4, Pages: 56-58(2013)
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- Published：2013
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WU Ri-na, NA Sheng-sang, BAO Le-chaolu. Optimization of Spray Drying Process for Compound Shaji Granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 56-58.
DOI：

WU Ri-na, NA Sheng-sang, BAO Le-chaolu. Optimization of Spray Drying Process for Compound Shaji Granules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 56-58. DOI：

摘要

目的: 优选复方沙棘颗粒剂的喷雾干燥工艺条件。方法: 以含水率和吸湿率为指标

通过单因素试验考察辅料种类及用量;以其总黄酮含量、含水率及出粉率的综合评分为指标

选取相对密度、进风温度、进料速度为考察因素

采用正交试验法优选复方沙棘颗粒剂的喷雾干燥工艺。结果: 浸膏相对密度和进风温度对喷雾干燥工艺影响极显著。最佳工艺条件为相对密度1.02(25℃)

进风温度100~110℃

进液速度22 mL·min-1

颗粒成型率32%。结论: 优选的干燥工艺稳定可行

可推广于大生产应用。

Abstract

Objective: To optimize spray srying technology conditions of compound Shaji granules. Method: With moisture content and moisture absorption rate as index

type and dosage of accessories were investigated by single factor test;With composite score of total flavonoids content

moisture content and flour yield as index

orthogonal test was used to optimize spray drying process with relative density

inlet air temperature and feed rate as factors. Result: Relative density of extract and inlet air temperature had significant effec on spray drying process.Optimum technology conditions were as followings:relative density 1.02(25℃)

inlet air temperature 100-110℃

feed rate 22 mL·min-1

forming rate of granules 32%. Conclusion: This optimized drying technology was stable and feasible

it could be used in industrial production.

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Related Author

SHAO Jie

ZHANG Ai-li

SHI Jing

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XIE Cai-xia

LIU Rui

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Related Institution

Pharmacy Technology Center，Tsinghua University

Center of Pharmacy R&D，XinJiang Huachun Bio-Pharmaceutical Co. Ltd.

School of Life Sciences， Tsinghua University

Institute of Medicinal Plant Development，Chinese Academy of Medical Sciences and Peking Union Medical College

China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co. Ltd.

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