Objective:To investigate the clinical efficacy and impact of Qingnao Jiangya tablets (QJT) on endothelial function in the treatment of liver yang hypertension. Method: One hundred and fifty-six patients with hypertension were randomly divided into treatment group of 79 cases and control group of 77 cases. Grade Ⅰ hypertension was treated with QJT; Grade Ⅱ hypertension was additionally treated by QJT based on the original treatment

The controls were only received placebo. QJT was orally given 4-6 tablets tid for 4 weeks. Blood pressure

liver yang score

nitric oxide (NO) and endothelin (ET-1) were evaluated for the two groups. Result: QJT significantly reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP) for the grade Ⅰ and grade II hypertension patients(P<0.01). QJT significantly improved the patient’s liver yang scores

and the disease efficiency and syndromes efficiencies were 84.81%

89.87%(P<0.01). QJT increased NO level

reduced ET-1 level and adjusted NO/ET-1 ratio(P<0.01). Conclusion: QJT had obvious antihypertensive effect for grade Ⅰ and grade Ⅱ hypertensive patients. It could improve clinical symptoms

and its mechanism may be achieved by adjusting the ratio of NO/ET-1.